聚肌苷酸-聚胞苷酸对肿瘤生长的抑制作用。
Inhibition of tumor growth by polyinosinic-polycytidylic acid.
作者信息
Levy H B, Law L W, Rabson A S
出版信息
Proc Natl Acad Sci U S A. 1969 Feb;62(2):357-61. doi: 10.1073/pnas.62.2.357.
Abstract
The synthetic double-stranded RNA, polyinosinic-cytidylic acid, inhibits the growth of some tumors in mice. Two days after implantation of a reticulum cell sarcoma, a lymphatic lymphoma, a fibrosarcoma, two leukemias, and a human adenovirus 12-induced tumor, treatment of groups of mice resulted in decreased growth rates of the tumors and increased survival times of the animals. In the two tumors tested (the reticulum cell sarcoma and the adenovirus 12-induced tumor) initiation of treatment after the tumor was grown to moderate size caused a regression of the tumor. In the case of the reticulum cell sarcoma, the tumor had not reappeared in some of the animals two months after cessation of treatment.
摘要
合成双链RNA，聚肌苷酸-聚胞苷酸，可抑制小鼠体内某些肿瘤的生长。在植入网状细胞肉瘤、淋巴性淋巴瘤、纤维肉瘤、两种白血病以及人腺病毒12诱导的肿瘤两天后，对几组小鼠进行治疗，结果肿瘤生长速率降低，动物存活时间延长。在测试的两种肿瘤（网状细胞肉瘤和腺病毒12诱导的肿瘤）中，肿瘤生长到中等大小时开始治疗可使肿瘤消退。就网状细胞肉瘤而言，在停止治疗两个月后，部分动物体内的肿瘤未再出现。
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