在51对有反复自然流产史的已婚夫妇中检测到的染色体变异和异常。
Chromosome variants and abnormalities detected in 51 married couples with repeated spontaneous abortions.
作者信息
Genest P
出版信息
Clin Genet. 1979 Dec;16(6):387-9. doi: 10.1111/j.1399-0004.1979.tb01346.x.
Abstract
Chromosome analysis of 51 married couples with repeated spontaneous abortions revealed a normal female karyotype in all wives, whereas 39 (76.5%) husbands showed a normal Y chromosome, 10 (19.6%) a Yq+, one (1.9%) a Yqs and one (1.9%) two Y chromosomes. The high incidence of Yq+ found in this investigation correlates with previous reports and indicates that the risk of spontaneous abortions is increased when the male partner has a large Y chromosome.
摘要
对51对有反复自然流产史的已婚夫妇进行染色体分析，结果显示所有妻子的核型均为正常女性核型，而39名（76.5%）丈夫的Y染色体正常，10名（19.6%）为Yq+，1名（1.9%）为Yqs，1名（1.9%）有两条Y染色体。本次调查中发现的Yq+高发生率与之前的报道相关，表明当男性伴侣有一条大Y染色体时，自然流产的风险会增加。
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