Korman E F, McLick J
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1130-6. doi: 10.1073/pnas.67.3.1130.
A mechanism is presented for the ATP synthesis reaction of mitochondrial oxidative phosphorylation. This mechanism is a dynamic, stereospecific, microscopically reversible mechanism in which enzyme-bound substrates, ADP, and inorganic phosphate directly combine in a S(N)2 type of process which proceeds with retention of configuration at the phosphate phosphorus center. The mechanism involves unstable, pentacovalent trigonal bipyramidal reaction intermediates which are pseudorotationally related. The mechanism accounts for all of the observed net and equilibrium exchange reactions and their relative rates. All of the exchange reactions are directly referrable to the ATP synthesis mechanism, and are circumstantial traits of that mechanism.
提出了一种关于线粒体氧化磷酸化中ATP合成反应的机制。该机制是一种动态、立体专一性、微观可逆的机制，其中与酶结合的底物、ADP和无机磷酸在一个S(N)2型过程中直接结合，该过程在磷酸磷中心构型保持的情况下进行。该机制涉及不稳定的、五价三角双锥反应中间体，它们通过假旋转相互关联。该机制解释了所有观察到的净反应和平衡交换反应及其相对速率。所有的交换反应都直接与ATP合成机制相关，并且是该机制的间接特征。
