Schneider N, Teitelbaum A P, Neuman W F
Calcif Tissue Int. 1980;30(2):147-50. doi: 10.1007/BF02408619.
The tissue deposition and metabolism of 125I-labeled synthetic amino-terminal parathyroid hormone, bPTH(1-34), were studied in rats. In comparison with the intact hormone molecule bPTH(1-84), the synthetic fragment was (a) cleared more rapidly from serum; (b) degraded more rapidly in peripheral tissues; (c) deposited to a greater extent in kidney; (d) deposited to a much smaller extent in liver. In bone, the accumulation of total radioactivity was approximately the same with both labeled hormones. The possible physiological significance of these patterns of distribution and metabolism is discussed.
对大鼠体内125I标记的合成氨基末端甲状旁腺激素bPTH(1 - 34)的组织沉积和代谢进行了研究。与完整的激素分子bPTH(1 - 84)相比，合成片段具有以下特点：(a)从血清中清除得更快；(b)在外周组织中降解得更快；(c)在肾脏中的沉积程度更高；(d)在肝脏中的沉积程度小得多。在骨骼中，两种标记激素的总放射性积累大致相同。讨论了这些分布和代谢模式可能的生理意义。
