血红蛋白作用模型
Model for the action of hemoglobin.
作者信息
Saroff H A
出版信息
Proc Natl Acad Sci U S A. 1970 Dec;67(4):1662-8. doi: 10.1073/pnas.67.4.1662.
Abstract
A model is developed for hemoglobin which depends on six Bohr groups per tetramer of hemoglobin. These six groups are assumed to be located in six regions between the four subunits of hemoglobin. When the Bohr groups are assumed to be perturbed in an asymmetrical manner on binding oxygen, these groups then generate the cooperative interactions of hemoglobin. This approach makes it possible to explain oxygen binding, the Bohr effect, specific salt effects, and aggregation effects in a unified manner.
摘要
开发了一种针对血红蛋白的模型，该模型取决于每个血红蛋白四聚体的六个玻尔基团。假定这六个基团位于血红蛋白四个亚基之间的六个区域。当假定玻尔基团在结合氧气时以不对称方式受到扰动时，这些基团便会产生血红蛋白的协同相互作用。这种方法能够以统一的方式解释氧气结合、玻尔效应、特定盐效应和聚集效应。
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Model for the action of hemoglobin.血红蛋白作用模型
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本文引用的文献
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The Oxygen Equilibrium of Hemoglobin and Its Structural Interpretation.血红蛋白的氧平衡及其结构解析
Proc Natl Acad Sci U S A. 1935 Apr;21(4):186-91. doi: 10.1073/pnas.21.4.186.
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Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 A resolution: the atomic model.分辨率为2.8埃的马氧合血红蛋白的三维傅里叶合成：原子模型
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Effect of ribonucleic acid depletion on ferritin induction in rat liver.
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Equilibrium of human hemoglobin with ethylisocyanide: further evidence for co-operativity in hemoglobin dimers.人血红蛋白与乙基异氰化物的平衡：血红蛋白二聚体协同性的进一步证据。
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Chemical modification of hemoglobins: a study of conformation restraint by internal bridging.血红蛋白的化学修饰：通过内部桥连对构象限制的研究
Proc Natl Acad Sci U S A. 1966 Aug;56(2):749-56. doi: 10.1073/pnas.56.2.749.
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