Morris R C, McSherry E, Sebastian A
Proc Natl Acad Sci U S A. 1971 Jan;68(1):132-5. doi: 10.1073/pnas.68.1.132.
In a woman with hereditary fructose intolerance and intact parathyroid function, the experimental administration of fructose at different dosage schedules invariably induced the dose-dependent, complex dysfunction of the proximal renal tubule now recognized as characteristic. But in a woman with hereditary fructose intolerance and hypoparathyroidism given similar amounts of fructose, the experimental dysfunction was strikingly attenuated or nondemonstrable unless or until fructose and parathyroid hormone were administered in sustained combination. Thereupon, a renal dysfunction of characteristic type and severity occurred invariably and almost immediately. Thus, the concentration of circulating parathyroid hormone can modulate the functional expression of the experimental renal disorder. This effect of parathyroid hormone, which appears to involve more than simple physiologic summation, may have important clinical implications.
在一名患有遗传性果糖不耐受且甲状旁腺功能正常的女性中，按照不同剂量方案对其进行果糖试验性给药，总是会诱发剂量依赖性的、现已被认定为典型特征的近端肾小管复杂功能障碍。但是，在一名患有遗传性果糖不耐受且甲状旁腺功能减退的女性中，给予其相似剂量的果糖时，除非持续联合给予果糖和甲状旁腺激素，否则试验性功能障碍会显著减轻或无法显现。随即，总是会几乎立即出现典型类型和严重程度的肾功能障碍。因此，循环中的甲状旁腺激素浓度可调节试验性肾脏疾病的功能表现。甲状旁腺激素的这种作用似乎不仅仅涉及简单的生理叠加，可能具有重要的临床意义。
