在黑腹果蝇细胞分化过程中，额外的Y染色体缺乏对位置效应斑驳的细胞间抑制作用。
Lack of intercellular suppression of position-effect variegation by supernumerary Y chromosomes during cell differentiation in Drosophila melanogaster.
作者信息
Gearhart J D, MacIntyre R J
出版信息
Proc Natl Acad Sci U S A. 1971 Jan;68(1):13-5. doi: 10.1073/pnas.68.1.13.
The objective of this research was to determine whether there is intercellular suppression of position-effect variegation by extra-heterochromatin during cell differentiation (pupation) in Drosophila melanogaster. The results provide some indication as to the mechanism and timing for the general suppression of position-effect variegation by supernumerary heterochromatin in the genome. Imaginal discs were excised from larvae having the necessary chromosomal rearrangement required for position-effect variegation and were transplanted into larvae with and without additional Y chromosomes in their genomes. After metamorphosis, the explants were examined to determine the effect of their respective hosts. There were no differences in the extent of variegation between eyes transplanted into hosts carrying different amounts of extra-heterochromatin. Thus, extra-heterochromatin position-effect variegation does not suppress during cell differentiation or, if it does, the action is intracellular.
本研究的目的是确定在黑腹果蝇细胞分化（化蛹）过程中，额外异染色质是否存在对位置效应斑驳的细胞间抑制作用。研究结果为基因组中多余异染色质对位置效应斑驳的普遍抑制机制和时间提供了一些线索。从具有位置效应斑驳所需必要染色体重排的幼虫中切除成虫盘，并将其移植到基因组中有无额外Y染色体的幼虫体内。变态后，检查外植体以确定其各自宿主的影响。移植到携带不同数量额外异染色质宿主中的眼睛，其斑驳程度没有差异。因此，额外异染色质位置效应斑驳在细胞分化过程中不会受到抑制，或者即便有抑制作用，也是在细胞内起作用。
Zotero 插件