生化网络中的约束与控制模型。

Model for constraint and control in biochemical networks.

作者信息

Newman S A, Rice S A

出版信息

Proc Natl Acad Sci U S A. 1971 Jan;68(1):92-6. doi: 10.1073/pnas.68.1.92.

DOI:10.1073/pnas.68.1.92

PMID:5276306

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC391169/

Abstract

A model is proposed for biochemical networks which takes into account substrate and modifier effects on enzyme activity and the different time scales on which the relevant processes occur. Sources of global constraint that can be utilized in metabolic regulation are indicated, and the relation of the model to the experiments of Kauffman on switching networks is analyzed. The biological significance of the model and possible systems in which it might be tested are discussed.

摘要

提出了一种用于生化网络的模型，该模型考虑了底物和调节剂对酶活性的影响以及相关过程发生的不同时间尺度。指出了可用于代谢调节的全局约束来源，并分析了该模型与考夫曼关于开关网络实验的关系。讨论了该模型的生物学意义以及可能测试该模型的系统。