金精三羧酸：蛋白质合成起始的抑制剂。
Aurintricarboxylic acid: inhibitor of initiation of protein synthesis.
作者信息
Stewart M L, Grollman A P, Huang M T
出版信息
Proc Natl Acad Sci U S A. 1971 Jan;68(1):97-101. doi: 10.1073/pnas.68.1.97.
Abstract
Aurintricarboxylic acid prevents the attachment of bacteriophage messenger RNA to ribosomes. As a consequence, initiation of protein synthesis in cell-free extracts prepared from Escherichia coli or rabbit reticulocytes is inhibited at concentrations of dye that do not prevent chain extension. Its properties can be distinguished from other agents that inhibit protein synthesis, including sodium fluoride, cycloheximide, and pactamycin.
摘要
金精三羧酸可阻止噬菌体信使核糖核酸与核糖体的附着。因此，在从大肠杆菌或兔网织红细胞制备的无细胞提取物中，当染料浓度尚未阻止链延伸时，蛋白质合成的起始就受到了抑制。其特性可与其他抑制蛋白质合成的试剂区分开来，这些试剂包括氟化钠、放线菌酮和密旋霉素。
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