Goodlett M, Dowling K, Downey J M
Eur J Pharmacol. 1979 Dec 7;60(2-3):257-60. doi: 10.1016/0014-2999(79)90228-0.
The hypothesis that hydrogen peroxide might lend inotropic support to ischemically depressed myocardium was critically tested in a canine model. A coronary branch was perfused at reduced flow to depress mechanical function. Since hydrogen peroxide infusion into the perfusate failed to alter the segment's contractile force, it was concluded that the previously described beneficial effects of hydrogen peroxide infusions are probably not related to a restoration of contractility in ischemic myocardium.
在犬类模型中对过氧化氢可能为缺血性心肌抑制提供正性肌力支持这一假说进行了严格验证。通过降低流量灌注冠状动脉分支以抑制机械功能。由于向灌注液中注入过氧化氢未能改变节段的收缩力，因此得出结论，先前所述的过氧化氢注入的有益作用可能与缺血心肌收缩力的恢复无关。
