心得安和美托洛尔对清醒心肌缺血犬左心室功能及冠状动脉血流动力学的影响。
The effects of propranolol and acebutolol on left ventricular function and coronary haemodynamics in the conscious dog with myocardial ischaemia.
作者信息
Hillis W S, Hutton I, Lawrie T D
出版信息
Br J Pharmacol. 1980 Mar;68(3):373-9. doi: 10.1111/j.1476-5381.1980.tb14550.x.
Abstract
1 The cardiovascular effects of the beta-adrenoceptor blocking drugs, propranolol and acebutolol, on regional coronary blood flow and left ventricular function have been investigated in the conscious dog with developing myocardial infarction. 2 Propranolol (1 to 1.5 mg/kg) or acebutolol (4 to 5 mg/kg) were administered intravenously 2 to 3 h after occlusion of the left anterior descending coronary artery. 3 Propranolol or acebutolol administration resulted in a relative increase in flow to the ischaemic area of the myocardium, particularly to the subendocardium. 4 Propranolol produced a greater reduction in heart rate and myocardial contractility than acebutolol. 5 These results demonstrate that beta-adrenoceptor blocking drugs reduce myocardial oxygen consumption and increase coronary flow to the ischaemic area of the myocardium after coronary artery occlusion in the conscious dog.
摘要
- 已在清醒的、患有进展性心肌梗死的犬中研究了β-肾上腺素能受体阻断药物普萘洛尔和醋丁洛尔对局部冠状动脉血流和左心室功能的心血管效应。2. 在左冠状动脉前降支闭塞2至3小时后静脉注射普萘洛尔（1至1.5毫克/千克）或醋丁洛尔（4至5毫克/千克）。3. 给予普萘洛尔或醋丁洛尔导致心肌缺血区域的血流相对增加，尤其是心内膜下血流。4. 普萘洛尔比醋丁洛尔能更显著地降低心率和心肌收缩力。5. 这些结果表明，在清醒犬冠状动脉闭塞后，β-肾上腺素能受体阻断药物可降低心肌耗氧量并增加心肌缺血区域的冠状动脉血流。
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