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Decrease in muscarinic cholinergic response of the rat heart following treatment with 6-hydroxydopa.

作者信息

Nomura Y, Kajiyama H, Segawa T

出版信息

Eur J Pharmacol. 1979 Dec 20;60(4):323-7. doi: 10.1016/0014-2999(79)90236-x.

DOI:10.1016/0014-2999(79)90236-x
PMID:527668
Abstract

Pretreatment with 6-hydroxydopa (6-OHDOPA) at birth produced a decrease in the number of [3H]quinuclidinyl benzilate ([3H]QNB) binding sites in adult rat heart homogenates. The treatment caused hyposensitivity to acetylcholine (ACh) but did not alter the maximal negative inotropic action of ACh in isolated atria of the rat. These results suggest that 6-OHDOPA affects the negative inotropic response to ACh by modifying the receptor number or through an effect on a step between receptor activation and biological response.

摘要

相似文献

1
Decrease in muscarinic cholinergic response of the rat heart following treatment with 6-hydroxydopa.
Eur J Pharmacol. 1979 Dec 20;60(4):323-7. doi: 10.1016/0014-2999(79)90236-x.
2
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Biochem Biophys Res Commun. 1980 Feb 27;92(4):1136-42. doi: 10.1016/0006-291x(80)90405-2.

引用本文的文献

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A comparison between muscarinic receptor occupancy, adenylate cyclase inhibition, and inotropic response in human heart.人体心脏中毒蕈碱受体占有率、腺苷酸环化酶抑制作用与变力性反应之间的比较。
Naunyn Schmiedebergs Arch Pharmacol. 1984 Feb;325(2):170-5. doi: 10.1007/BF00506197.