Nomura Y, Segawa T
Eur J Pharmacol. 1978 Aug 15;50(4):431-5. doi: 10.1016/0014-2999(78)90149-8.
Atropine-induced locomotor stimulation was investigated in the developing rat pretreated with 6-hydroxydopa at birth. The locomotor stimulation by atropine was first observed on day 20 and gradually increased with age. The treatment with 6-hydroxydopa potentiated atropine-induced locomotor stimulation on days later than day 20 and inhibited a pilocarpine-induced catalepsy on day 30. This suggests that central cholinergic neurons, probably in the neostriatum, reach functional maturity between 15 and 20 days, and that the pretreatment with 6-hydroxydopa induced muscarinic hyposensitivity in the developing rat.
对出生时用6-羟基多巴胺预处理的发育中大鼠进行了阿托品诱导的运动刺激研究。阿托品引起的运动刺激首次在第20天观察到，并随年龄逐渐增加。6-羟基多巴胺处理在第20天之后增强了阿托品诱导的运动刺激，并在第30天抑制了毛果芸香碱诱导的僵住症。这表明，可能在新纹状体中的中枢胆碱能神经元在15至20天之间达到功能成熟，并且用6-羟基多巴胺预处理可诱导发育中大鼠的毒蕈碱低敏性。
