化学包被的同基因肿瘤细胞增强的免疫原性。
Enhanced immunogenicity of chemically-coated syngeneic tumor cells.
作者信息
Martin W J, Wunderlich J R, Fletcher F, Inman J K
出版信息
Proc Natl Acad Sci U S A. 1971 Feb;68(2):469-72. doi: 10.1073/pnas.68.2.469.
Abstract
The immunogenicity of the EL-4 strain of mouse lymphoid leukemia cells in syngeneic C57BL/6 recipients was enhanced by in vitro coating of the cells with either Concanavalin A or dinitrophenylaminocaproate. The tumor-specific immune response was quantitated using a recently developed assay that involves in vitro cell-mediated cytotoxicity.
摘要
通过用伴刀豆球蛋白A或二硝基苯氨基己酸酯在体外包被细胞，可增强小鼠淋巴细胞白血病EL-4株在同基因C57BL/6受体中的免疫原性。使用一种最近开发的涉及体外细胞介导细胞毒性的检测方法对肿瘤特异性免疫反应进行定量。
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