在预先用酪氨酰或二硝基苯基包被的肿瘤细胞免疫的宿主中，肿瘤生长不受阻碍。
Unimpeded growth of tumour in hosts pre-immunized with tyrosyl- or dinitrophenyl-coated tumour cells.
作者信息
Bauminger S, Yachnin S
出版信息
Br J Cancer. 1972 Apr;26(2):77-83. doi: 10.1038/bjc.1972.12.
Abstract
Techniques are described for hapten attachment to the cell membranes of mouse tumour cells. Dinitrophenylation and tyrosylation could be achieved without substantial loss of viability as measured by dye exclusion. In addition hapten coated tumour cells were capable of initiating new tumour formation in syngeneic hosts. Pre-immunization of recipient mice with hapten coated tumour cells did not increase their resistance to tumour formation upon subsequent challenge with graded doses of untreated tumour cells.
摘要
本文描述了将半抗原附着于小鼠肿瘤细胞膜的技术。通过染料排斥法测定，二硝基苯化和酪氨酰化可在不显著丧失活力的情况下实现。此外，包被半抗原的肿瘤细胞能够在同基因宿主中引发新的肿瘤形成。用包被半抗原的肿瘤细胞对受体小鼠进行预免疫，在随后用不同剂量的未处理肿瘤细胞进行攻击时，并未增加它们对肿瘤形成的抵抗力。
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Unimpeded growth of tumour in hosts pre-immunized with tyrosyl- or dinitrophenyl-coated tumour cells.在预先用酪氨酰或二硝基苯基包被的肿瘤细胞免疫的宿主中，肿瘤生长不受阻碍。
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[Isolation, from anti-dinitrophenyl sera taken at the beginning of immunization, of a protein combining with the hapten and which is not related to immunoglobulins].[从免疫开始时采集的抗二硝基苯基血清中分离出一种与半抗原结合且与免疫球蛋白无关的蛋白质]
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本文引用的文献
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