Rampton D S, Kasidas G P, Rose G A, Sarner M
Gut. 1979 Dec;20(12):1089-94. doi: 10.1136/gut.20.12.1089.
To investigate the possibility of measuring urinary oxalate output instead of faecal fat excretion as an outpatient screening test for steatorrhoea, we determined 24 hour urinary oxalate and five day faecal fat excretion before and during an oral load of sodium oxalate 600 mg daily (oxalate 4.44 mmol), in 32 patients with suspected malabsorption on a diet containing oxalate 30 mg (0.33 mmol), fat 50 g (180 mmol), and calcium 1 g (25 mmol). Nineteen patients proved to have steatorrhoea (mean faecal fat 62 mmol/24 h, range 19--186 mmol) of varying aetiologies. On the diet alone, urinary oxalate was raised in only nine of these patients (mean 0.25 mmol/24 h, range 0.08--0.59 mmol) (normal less than 0.20). By contrast, when the diet was supplemented with oral sodium oxalate, all 19 patients with steatorrhoea had hyperoxaluria (mean 0.91 mmol/24 h, range 0.46--1.44 mmol) (normal less than 0.44). There was a significant positive linear relationship between urinary oxalate and faecal fat when the 32 patients were on the high oxalate intake (r = 0.73, P less than 0.001), but not when they were on the low oxalate intake. Mean percentage absorption of orally administered oxalate was 5.8 +/- 0.99% (+/- 1 SD) in normal subjects and 14.7 +/- 6.0% (P less than 0.002) in patients with steatorrhoea. Measurement of urinary oxalate output during oral sodium oxalate loading appears to be a reliable and convenient screening test for steatorrhoea.
为了研究测量尿草酸盐排出量而非粪便脂肪排泄量作为门诊脂肪泻筛查试验的可能性，我们测定了32例怀疑有吸收不良的患者在每日口服600mg草酸钠（草酸盐4.44mmol）负荷前后的24小时尿草酸盐和5天粪便脂肪排泄量，这些患者的饮食中含有30mg（0.33mmol）草酸盐、50g（180mmol）脂肪和1g（25mmol）钙。19例患者被证实有不同病因的脂肪泻（平均粪便脂肪62mmol/24小时，范围19 - 186mmol）。仅在该饮食条件下，这些患者中只有9例尿草酸盐升高（平均0.25mmol/24小时，范围0.08 - 0.59mmol）（正常小于0.20）。相比之下，当饮食中补充口服草酸钠时，所有19例脂肪泻患者都出现高草酸尿症（平均0.91mmol/24小时，范围0.46 - 1.44mmol）（正常小于0.44）。当32例患者摄入高草酸盐时，尿草酸盐与粪便脂肪之间存在显著的正线性关系（r = 0.73，P小于0.001），但在低草酸盐摄入时则不存在。正常受试者口服草酸盐的平均吸收百分比为5.8±0.
