Hylander E, Jarnum S, Keldsbo I L, Thale M
Scand J Gastroenterol. 1978;13(4):423-31. doi: 10.3109/00365527809181916.
143 patients (70 patients with Crohn's disease, 11 with ulcerative colitis, 40 with an intestinal by-pass operation, 9 with non-tropical sprue, 10 with short bowel syndrome, and 3 with other gastrointestinal disease) were studied during a metabolic regime including a fixed oral supply of 70 g fat, 800 mg calcium, and 200 mg oxalate. Faecal fat, 47Ca-absorption, 14C-oxalate absorption, and renal oxalate excretion were measured, and in the majority of patients a 14C-glyco-cholic acid breath test was also performed. 14Ca-absorption was practically identical (r = 0.92), whether determined by whole-body counting or from the accumulation of absorbed 47Ca in the skeleton of the underarm. 14C-oxalate absorption and renal oxalate excretion agreed well (r = 0.85). Steatorrhoea correlated weakly with renal oxalate excretion (r = 0.63, p less than 0.001), whereas no correlation was present between faecal fat and calcium absorption or between oxalate and calcium absorption under the constant conditions prevailing during the study. It is recommended that a "trifixed" regime with absorption studies of fat, calcium, and oxalate be undertaken previous to therapy that aims at a reduction of steatorrhoea or hyperoxaluria or an improvement of calcium absorption in chronic malabsorption syndromes, not least because therapy of these categories of patients most often continues for years.
143例患者（70例克罗恩病患者、11例溃疡性结肠炎患者、40例接受肠道旁路手术患者、9例非热带性口炎性腹泻患者、10例短肠综合征患者以及3例其他胃肠道疾病患者）在一种代谢方案中接受了研究，该方案包括固定口服70克脂肪、800毫克钙和200毫克草酸盐。测量了粪便脂肪、47钙吸收、14碳草酸盐吸收以及肾草酸盐排泄，并且在大多数患者中还进行了14碳甘氨胆酸呼气试验。无论通过全身计数还是通过腋下骨骼中吸收的47钙的积累来测定，47钙吸收实际上是相同的（r = 0.92）。14碳草酸盐吸收和肾草酸盐排泄相关性良好（r = 0.85）。脂肪泻与肾草酸盐排泄的相关性较弱（r = 0.63，p < 0.001），而在研究期间普遍存在的恒定条件下，粪便脂肪与钙吸收之间或草酸盐与钙吸收之间不存在相关性。建议在旨在减少脂肪泻或高草酸尿症或改善慢性吸收不良综合征中钙吸收的治疗之前，采用对脂肪、钙和草酸盐进行吸收研究的“三固定”方案，尤其是因为这类患者的治疗通常会持续数年。
