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兔精浆中的大分子受精抑制剂。

Macromolecular inhibitor of fertilization in rabbit seminal plasma.

作者信息

Davis B K

出版信息

Proc Natl Acad Sci U S A. 1971 May;68(5):951-5. doi: 10.1073/pnas.68.5.951.

Abstract

A large (86S) glycoprotein isolated from rabbit seminal plasma acts on sperm cells to block fertilization. The proportion of fertilized eggs recovered from does 1 day after tubal insemination of sperm 5-6 hr before or 2-3 hr after ovulation was significantly depressed when uterine-capacitated spermatozoa were exposed to this substance at concentrations of 20-72 mug of protein/ml. Rabbit seminal plasma was estimated to have about 2 mg/ml of this factor. Another large glycoprotein ( approximately 138S) is also present in rabbit seminal plasma; the function of this molecule awaits elucidation.

摘要

从兔精浆中分离出的一种大分子(86S)糖蛋白作用于精子细胞以阻止受精。当子宫获能精子在排卵前5 - 6小时或排卵后2 - 3小时暴露于浓度为20 - 72微克蛋白质/毫升的这种物质时,输卵管授精1天后从母兔回收的受精卵比例显著降低。据估计,兔精浆中这种因子的含量约为2毫克/毫升。兔精浆中还存在另一种大分子糖蛋白(约138S);该分子的功能尚待阐明。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5099/389088/1e12247664e7/pnas00080-0086-a.jpg

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