Odumosu A, Wilson C W
Int J Obes. 1979;3(2):123-31.
Following initial weight gain, reduction in appetite and pronounced weight loss occurred in scorbutic unsupplemented guinea-pigs. Hepatic ascorbic acid levels were significantly reduced and cholesterol concentration increased in the liver. Fenfluramine administration caused immediate loss of weight and appetite in the scorbutic guinea-pigs, these changes being more pronounced in the males. Hepatic ascorbic acid, cholesterol and triglycerides were reduced to lower levels in the fenfluramine-treated scorbutic animals than in the scorbutic guinea-pigs receiving diet alone. In contrast, weight and appetite increased in vitamin-C-supplemented animals while they were receiving fenfluramine. Their hepatic cholesterol and triglyceride levels became significantly reduced. It has been shown that supplementary vitamin C can inhibit the anti-obesity and anorectic actions of fenfluramine and counteract its effect in raising tissue cholesterol.
在最初体重增加之后，未补充维生素C的坏血病豚鼠出现食欲减退和明显体重减轻。肝脏中抗坏血酸水平显著降低，肝脏中胆固醇浓度升高。给予芬氟拉明导致坏血病豚鼠立即体重减轻和食欲下降，这些变化在雄性豚鼠中更为明显。与仅接受饮食的坏血病豚鼠相比，经芬氟拉明治疗的坏血病动物肝脏中的抗坏血酸、胆固醇和甘油三酯水平降至更低水平。相比之下，补充维生素C的动物在接受芬氟拉明时体重和食欲增加。它们肝脏中的胆固醇和甘油三酯水平显著降低。研究表明，补充维生素C可以抑制芬氟拉明的抗肥胖和食欲抑制作用，并抵消其升高组织胆固醇的作用。
