Odumosu A
Acta Vitaminol Enzymol. 1981;3(2):96-102.
A comparison has been made of the effects of d(+) fenfluramine, Mazindol and Diethylpropion on the changes in body weight and brain ascorbic acid concentrations in male and female guinea pigs receiving vitamin C-deficient diet daily with or without daily supplementary vitamin C for 24 days. Bodyweight increases initially; the subsequent decrease was more rapid in scorbutic male than in the female guinea pigs. The weight-reducing drugs prevented the initial rise in weight of these ascorbutic guinea pigs. Fenfluramine caused the greatest fall in weight in both sexes, the effect being more pronounced in the males. Supplementary vitamin C reduced the anti-obesity actions of fenfluramine, Mazindol and Diethylpropion. Brain ascorbic acid level in scorbutic guinea pigs was more significantly reduced by fenfluramine than by either Mazindol or Diethylpropion after 24 days administration. These drugs prevented the rise in brain ascorbic acid normally produced by supplementary vitamin C. The reduction brain ascorbic acid appears to be related to the loss of weight more in the males than in the females.
对右旋芬氟拉明、马吲哚和二乙胺苯丙酮，在每日给予维生素C缺乏饮食的雄性和雌性豚鼠中，无论是否每日补充维生素C持续24天，对体重变化和脑内抗坏血酸浓度的影响进行了比较。体重最初会增加；随后坏血病雄性豚鼠体重下降比雌性豚鼠更快。减肥药物阻止了这些患坏血病豚鼠体重的最初增加。芬氟拉明导致两性体重下降幅度最大，在雄性中效果更明显。补充维生素C降低了芬氟拉明、马吲哚和二乙胺苯丙酮的抗肥胖作用。给药24天后，坏血病豚鼠脑中抗坏血酸水平被芬氟拉明降低的程度比马吲哚或二乙胺苯丙酮更显著。这些药物阻止了补充维生素C通常引起的脑内抗坏血酸升高。脑内抗坏血酸的降低在雄性中似乎比雌性中与体重减轻的关系更大。
