Hart M M, Adamson R H
Proc Natl Acad Sci U S A. 1971 Jul;68(7):1623-6. doi: 10.1073/pnas.68.7.1623.
The toxicity and antitumor activity of salts of the Group IIIa metals aluminum, gallium, indium, and thallium were determined. With the (lethal dose)(50) as a measure, the decreasing order of toxicity was TlCl(3) >/= In(NO(3))(3) > Ga(NO(3))(3) > Al(NO(3))(3). All four metals exhibited antitumor activity, but when the tumor was inoculated by a route different from that of the drug, only Ga(+3) and, to a lesser extent, In(+3) inhibited tumor growth. Ga(NO(3))(3) was found to inhibit the growth of three out of four rodent solid tumors. Gallium therefore has potential therapeutic usefulness for treatment of solid tumors in man.
测定了ⅢA族金属铝、镓、铟和铊的盐类的毒性和抗肿瘤活性。以半数致死量作为衡量指标，毒性递减顺序为TlCl₃≥In(NO₃)₃＞Ga(NO₃)₃＞Al(NO₃)₃。所有这四种金属均表现出抗肿瘤活性，但当肿瘤接种途径与给药途径不同时，只有Ga(+3)以及在较小程度上In(+3)能抑制肿瘤生长。发现Ga(NO₃)₃能抑制四种啮齿动物实体瘤中的三种。因此，镓在治疗人类实体瘤方面具有潜在的治疗用途。
