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Interaction between phenobarbital and diphenylhydantoin in animals and in epileptic patients.

作者信息

Morselli P L, Rizzo M, Garattini S

出版信息

Ann N Y Acad Sci. 1971 Jul 6;179:88-107. doi: 10.1111/j.1749-6632.1971.tb46892.x.

DOI:10.1111/j.1749-6632.1971.tb46892.x
PMID:5285399
Abstract
摘要

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Interaction between phenobarbital and diphenylhydantoin in animals and in epileptic patients.苯巴比妥与苯妥英在动物及癫痫患者体内的相互作用。
Ann N Y Acad Sci. 1971 Jul 6;179:88-107. doi: 10.1111/j.1749-6632.1971.tb46892.x.
2
Further observations on the interactions between phenobarbital and diphenylhydantoin during chronic treatment in the rat.关于苯巴比妥与苯妥英在大鼠长期治疗过程中相互作用的进一步观察
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Serum levels of diphenylhydantoin and phenobarbital in epileptic children receiving diphenylhydantoin, phenobarbital and-or mysoline.接受苯妥英钠、苯巴比妥和/或扑米酮治疗的癫痫儿童的血清苯妥英钠和苯巴比妥水平。
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[Clinical and pharmacodynamic correlations of phenobarbital (PB) and diphenylhydantoin (DPH) in the treatment of infantile epilepsy].[苯巴比妥（PB）和苯妥英（DPH）治疗婴儿癫痫的临床与药效学相关性]
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Correlation of anticonvulsant levels in human plasma and epileptogenic brain.
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[Determination of serum levels of phenobarbital and diphenylhydantoin in the treatment of epilepsy].[癫痫治疗中苯巴比妥和苯妥英血清水平的测定]
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Relationships between serum and cerebrospinal fluid anticonvulsant drug and folic acid concentrations in epileptic patients.
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[A study on cerebrospinal fluid and saliva to serum concentration ratios of anticonvulsants--Phenytoin, Phenobarbital, Valproic Acid and Primidone in epileptic patients].
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Antiepileptic drugs. A review of clinically significant drug interactions.抗癫痫药物。具有临床意义的药物相互作用综述。
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Effect of diphenylhydantoin and its main hydroxylated metabolite on the pharmacokinetics and the urinary and biliary excretion of phenobarbital and its p-hydroxy metabolite.苯妥英及其主要羟基化代谢产物对苯巴比妥及其对羟基代谢产物的药代动力学、尿液及胆汁排泄的影响。
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Phenytoin: an inhibitor and inducer of primidone metabolism in an epileptic patient.苯妥英：一名癫痫患者中扑米酮代谢的抑制剂和诱导剂。
Br J Clin Pharmacol. 1982 Aug;14(2):294-7. doi: 10.1111/j.1365-2125.1982.tb01980.x.