苯妥英对苯巴比妥和扑米酮代谢的影响。
The effects of phenytoin on phenobarbitone and primidone metabolism.
作者信息
Lambie D G, Johnson R H
出版信息
J Neurol Neurosurg Psychiatry. 1981 Feb;44(2):148-51. doi: 10.1136/jnnp.44.2.148.
Abstract
Serum concentrations of primidone and its metabolites-phenobarbitone and phenylethylmalonamide-were measured in 40 epileptic patients receiving treatment with primidone alone or primidone plus phenytoin. Serum phenobarbitone concentrations were also measured in 100 patients receiving phenobarbitone, alone or with phenytoin showed raised serum phenobarbitone concentrations. Phenytoin also caused raised phenylethylmalonamide concentrations in patients on primidone.
摘要
对40例单独接受扑米酮治疗或扑米酮加苯妥英治疗的癫痫患者测定了血清中扑米酮及其代谢产物苯巴比妥和苯乙基丙二酰胺的浓度。还对100例单独接受苯巴比妥治疗或苯巴比妥与苯妥英联合治疗的患者测定了血清苯巴比妥浓度，结果显示血清苯巴比妥浓度升高。苯妥英也使服用扑米酮的患者体内苯乙基丙二酰胺浓度升高。
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