Riggs B L, Marshall J H, Jowsey J, Heaney R P, Bassingthwaighte J B
J Lab Clin Med. 1971 Oct;78(4):585-98.
Bone from 7 terminally ill men who received Ca ½ to 23 days before death was studied by quantitative autoradiography. Short-term exchangeable calcium was located on bone surfaces, and had an apparent mass of 3.4 Gm. The time of maximal surface Ca activity was 2.5 days. Diffuse activity of low intensity from long-term exchange accounted for 16.9 ± 3.3 per cent (mean ± S.E.) of total uptake; in the 2 patients having plasma Ca measurements; the rate of diffuse uptake ranged from 10 to 25 per cent of the normal accretion rate. However, focal activity of intermediate intensity accounted for 49.8 to 68.4 per cent of uptake and was believed to be due to both long-term exchange and secondary mineralization. An unexpected finding was that 7.5 ± 1.6 per cent of activity was associated with bone resorption surfaces. Because of the terminal illness, bone formation was suppressed, and only 5.9 ± 2.4 per cent of activity was associated with hot spots.
对7名在死亡前½至23天接受钙治疗的晚期男性的骨骼进行了定量放射自显影研究。短期可交换钙位于骨表面，表观质量为3.4克。最大表面钙活性出现的时间为2.5天。长期交换产生的低强度弥散活性占总摄取量的16.9±3.3%（平均值±标准误）；在2例进行了血浆钙测量的患者中，弥散摄取率为正常骨生长率的10%至25%。然而，中等强度的局灶性活性占摄取量的49.8%至68.4%，被认为是长期交换和继发性矿化共同作用的结果。一个意外发现是，7.5±1.6%的活性与骨吸收表面有关。由于处于晚期疾病状态，骨形成受到抑制，只有5.9±2.4%的活性与热点有关。
