在表达T/t位点抗原的畸胎瘤细胞系上缺乏能够与细胞毒性T细胞发生反应的H-2抗原。
Absence of H-2 antigens capable of reacting with cytotoxic T cells on a teratoma line expressing a T/t locus antigen.
作者信息
Forman J, Vitetta E S
出版信息
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3661-5. doi: 10.1073/pnas.72.9.3661.
Abstract
An established cell line of murine teratoma cells (F9), which lacks serologically detectable H-2 that is determined by a wild-type T/t locus gene. These cells are not killed and do not react with cytotoxic T cells sensitized to H-2 antigens in a cell-mediated lympholysis assay. Modification of spleen cells from the strain or origin (129) of this teratoma line with trinitrobenzene sulfonic acid allows the generation of syngeneic killer cells that display a cytotoxic effect against trinitrophenyl-modified splenic targets, but not against trinitrophenyl-modified F9 targets. Thus, the F9 antigen is structurally similar to H-2b but does not act as a target antigen in the cell-mediated lympholysis assay for anti-H-2b cytotoxic T cells, nor does it crossreact with H-2b antigens at the T cell level.
摘要
一种已建立的小鼠畸胎瘤细胞系（F9），其缺乏由野生型T/t位点基因决定的血清学可检测的H-2。在细胞介导的淋巴细胞溶解试验中，这些细胞不会被杀死，也不会与对H-2抗原致敏的细胞毒性T细胞发生反应。用三硝基苯磺酸修饰该畸胎瘤细胞系的来源品系（129）的脾细胞，可产生同基因杀伤细胞，这些杀伤细胞对三硝基苯基修饰的脾细胞靶标具有细胞毒性作用，但对三硝基苯基修饰的F9靶标没有作用。因此，F9抗原在结构上与H-2b相似，但在抗H-2b细胞毒性T细胞的细胞介导的淋巴细胞溶解试验中不作为靶抗原，在T细胞水平上也不与H-2b抗原发生交叉反应。
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