芳香族氨基酸与中性聚腺苷酸的相互作用。
Interaction of aromatic amino acids with neutral polyadenylic acid.
作者信息
Raszka M, Mandel M
出版信息
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1190-1. doi: 10.1073/pnas.68.6.1190.
Abstract
The aromatic amino acids tryptophan, phenylalanine, and histidine interact with singlestranded polyadenylic acid [poly(A)] as observed by proton magnetic resonance spectroscopy. The chemical shift of the C(2) and C(8) protons of the adenine moiety of poly(A) is consistent with a destacking of the initially partly-stacked polynucleotide chain by the intercalation of the planar ring structure. The relative magnitude of this interaction is tryptophan>phenylalanine>histidine.
摘要
质子磁共振波谱观察发现，芳香族氨基酸色氨酸、苯丙氨酸和组氨酸可与单链聚腺苷酸[poly(A)]相互作用。聚腺苷酸腺嘌呤部分的C(2)和C(8)质子的化学位移表明，平面环状结构的嵌入使最初部分堆积的多核苷酸链发生解堆积。这种相互作用的相对强度为色氨酸>苯丙氨酸>组氨酸。
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本文引用的文献
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