向快速轴浆运输机制的局部能量供应。
Local supply of energy to the fast axoplasmic transport mechanism.
作者信息
Ochs S
出版信息
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1279-82. doi: 10.1073/pnas.68.6.1279.
Abstract
Local anoxia of a small region of cat sciatic nerves causes a block of fast axoplasmic transport in vitro. Activity becomes dammed up at the face of the anoxic region, and falls off rapidly distally just inside the anoxic region. Such blocks were reversible if they were removed within 1 hr. Earlier studies had given evidence that fast axoplasmic transport is closely dependent on ATP derived from oxidative metabolism. The present results indicate that ATP is required all along the length of the nerve fiber to supply a hypothesized "transporting filament" mechanism of fast transport.
摘要
猫坐骨神经小区域的局部缺氧会在体外导致快速轴浆运输受阻。活性在缺氧区域的前端受阻，在缺氧区域内稍远的位置则迅速下降。如果在1小时内解除这种受阻情况，是可逆的。早期研究已证明快速轴浆运输紧密依赖于氧化代谢产生的ATP。目前的结果表明，在神经纤维的整个长度上都需要ATP来为一种假定的快速运输“运输细丝”机制提供能量。
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