Fisher L J
J Embryol Exp Morphol. 1979 Dec;54:219-27.
In the central area of the retina of mouse the rate of synaptogenesis in the inner plexiform layer (IPL) drops precipitously at about the time the eyes open. To determine if the visual input at eye opening provides a signal for the neurons to stop adding synapses, mice were raised in darkness during the period of maximal synaptogenesis and through eye opening. Retinal synaptic arrays of dark-reared and normally reared animals were compared quantitatively. The rate of synaptogenesis after eye opening in dark-reared mice indicated that the onset of visual stimulation was not the cue to stop synaptogenesis. However, the synaptic arrays of the IPL of dark-reared mice consistently had more conventional synapses than those of normally reared mice. It is concluded that the number of conventional synapses in the central retina was increased by dark-rearing.
在小鼠视网膜的中央区域，内网状层（IPL）的突触形成速率在眼睛睁开时急剧下降。为了确定睁眼时的视觉输入是否为神经元停止添加突触提供信号，在突触形成高峰期和睁眼期间，将小鼠饲养在黑暗环境中。对黑暗饲养和正常饲养动物的视网膜突触阵列进行了定量比较。黑暗饲养小鼠睁眼后的突触形成速率表明，视觉刺激的开始并非停止突触形成的信号。然而，黑暗饲养小鼠的IPL突触阵列中，传统突触始终比正常饲养小鼠的更多。得出的结论是，黑暗饲养会增加中央视网膜中传统突触的数量。
