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相似文献

1
N-acetyl-D-galactosaminyltransferase in human serum and erythrocyte membranes.人血清和红细胞膜中的N-乙酰-D-半乳糖胺基转移酶
Proc Natl Acad Sci U S A. 1971 Aug;68(8):1753-6. doi: 10.1073/pnas.68.8.1753.
2
UDP-N-acetyl-D-galactosamine as a donor substrate for the glycosyltransferase encoded by the B gene at the human blood group ABO locus.UDP-N-乙酰-D-半乳糖胺作为人类ABO血型位点B基因编码的糖基转移酶的供体底物。
Carbohydr Res. 1986 Jun 1;149(1):149-70. doi: 10.1016/s0008-6215(00)90375-6.
3
Qualitative differences in the N-acetyl-D-galactosaminyltransferases produced by human A1 and A2 genes.人类A1和A2基因产生的N-乙酰-D-半乳糖胺基转移酶的定性差异。
Proc Natl Acad Sci U S A. 1973 Jan;70(1):220-4. doi: 10.1073/pnas.70.1.220.
4
Glycoprotein biosynthesis in small intestine. 3. Enzymatic basis for the difference in the antigenicity of mucins.小肠中的糖蛋白生物合成。3. 粘蛋白抗原性差异的酶学基础。
J Clin Invest. 1972 May;51(5):1135-45. doi: 10.1172/JCI106906.
5
Uridine diphosphate-N-acetyl-D-galactosamine: D-galactose alpha-3-N-acetyl-D-galactosaminyltransferase, a product of the gene that determines blood type A in man.尿苷二磷酸-N-乙酰-D-半乳糖胺：D-半乳糖α-3-N-乙酰-D-半乳糖胺基转移酶，人类中决定血型A的基因产物。
J Biol Chem. 1970 Mar 25;245(6):1484-90.
6
Properties of a CMP-N-acetylneuraminic acid: glycoprotein sialyltransferase in human serum and erythrocyte membranes.人血清和红细胞膜中CMP-N-乙酰神经氨酸：糖蛋白唾液酸转移酶的特性
Biochim Biophys Acta. 1971 Sep 21;244(3):505-12. doi: 10.1016/0304-4165(71)90067-5.
7
Enzymatic conversion of human blood-group-O erythrocytes into A 2 and A 1 cells by -N-acetyl-D-galactosaminyl transferases of blood-group-A individuals.利用A型个体的-N-乙酰-D-半乳糖胺基转移酶将人O型血红细胞酶促转化为A2型和A1型细胞。
Eur J Biochem. 1973 Apr 2;34(1):125-8. doi: 10.1111/j.1432-1033.1973.tb02738.x.
8
alpha-N-acetyl-D-galactosaminyl- and alpha-D-galactosyltransferase activities in sera of cis AB blood group individuals.顺式AB血型个体血清中的α-N-乙酰-D-半乳糖胺基转移酶和α-D-半乳糖基转移酶活性
J Immunogenet. 1978 Aug;5(4):221-31. doi: 10.1111/j.1744-313x.1978.tb00650.x.
9
Carbohydrate content of human erythrocyte membrane. Variations with ABO-blood group.人红细胞膜的碳水化合物含量。ABO血型的差异
Hoppe Seylers Z Physiol Chem. 1979 Apr;360(4):501-6. doi: 10.1515/bchm2.1979.360.1.501.
10
Characterisation of a blood-group A-active tetrasaccharide synthesised by a blood-group B gene-specified glycosyltransferase.由血型B基因指定的糖基转移酶合成的血型A活性四糖的表征。
Carbohydr Res. 1984 Jul 15;130:251-60. doi: 10.1016/0008-6215(84)85283-0.

引用本文的文献

1
Unravelling the biochemical basis of blood group ABO and Lewis antigenic specificity.解析血型ABO和Lewis抗原特异性的生化基础。
Glycoconj J. 2000 Jul-Sep;17(7-9):501-30. doi: 10.1023/a:1011014307683.
2
Fluorescence in situ hybridization for the Y-chromosome can be used to detect cells of recipient origin in allografted hearts following cardiac transplantation.用于Y染色体的荧光原位杂交技术可用于检测心脏移植后同种异体移植心脏中受体来源的细胞。
Am J Pathol. 1993 Apr;142(4):975-80.
3
Glycosyltransferases in human blood. II. Study of serum galactosyltransferase and N-acetylgalactosaminyltransferase in patients with liver diseases.人类血液中的糖基转移酶。II. 肝病患者血清半乳糖基转移酶和N-乙酰半乳糖胺基转移酶的研究。
J Clin Invest. 1972 Aug;51(8):2033-9. doi: 10.1172/JCI107009.
4
Glycosyltransferases in human blood.I. Galactosyltransferase in human serum and erythrocyte membranes.人类血液中的糖基转移酶。I. 人血清和红细胞膜中的半乳糖基转移酶。
J Clin Invest. 1972 Aug;51(8):2024-32. doi: 10.1172/JCI107008.
5
Qualitative differences in the N-acetyl-D-galactosaminyltransferases produced by human A1 and A2 genes.人类A1和A2基因产生的N-乙酰-D-半乳糖胺基转移酶的定性差异。
Proc Natl Acad Sci U S A. 1973 Jan;70(1):220-4. doi: 10.1073/pnas.70.1.220.
6
Alterations of membrane glycopeptides in human colonic adenocarcinoma.人结肠腺癌中膜糖肽的改变。
Proc Natl Acad Sci U S A. 1974 Dec;71(12):4869-73. doi: 10.1073/pnas.71.12.4869.
7
Glycoprotein biosynthesis in small intestine. 3. Enzymatic basis for the difference in the antigenicity of mucins.小肠中的糖蛋白生物合成。3. 粘蛋白抗原性差异的酶学基础。
J Clin Invest. 1972 May;51(5):1135-45. doi: 10.1172/JCI106906.
8
Cancer-associated isoenzyme of serum galactosyltransferase.血清半乳糖基转移酶的癌症相关同工酶
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1319-22. doi: 10.1073/pnas.73.4.1319.
9
Human plasma uridine diphosphate galactose-glycoprotein galactosyltransfertase. Purification, properties and kinetics of the enzyme-catalysed reaction.人血浆尿苷二磷酸半乳糖-糖蛋白半乳糖基转移酶。酶催化反应的纯化、性质及动力学
Biochem J. 1977 Dec 1;167(3):621-8. doi: 10.1042/bj1670621.

本文引用的文献

1
The isolation and properties of the human blood-group a substance.人类血型A物质的分离与特性
Biochem J. 1950 Apr;46(4):426-38. doi: 10.1042/bj0460426.
2
Detection of sugars on paper chromatograms.纸色谱上糖的检测
Nature. 1950 Sep 9;166(4219):444-5. doi: 10.1038/166444b0.
3
Substance from erythrocytes of blood group A.来自A型血红细胞的物质。
Nature. 1960 Aug 6;187:516-7. doi: 10.1038/187516b0.
4
The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes.人红细胞无血红蛋白空泡的制备及其化学特性
Arch Biochem Biophys. 1963 Jan;100:119-30. doi: 10.1016/0003-9861(63)90042-0.
5
Isolation and characterization of glycolipids from erythrocytes of human blood A (plus) and B (plus).从人A（阳性）和B（阳性）血型红细胞中分离和鉴定糖脂
J Biol Chem. 1961 Nov;236:2827-34.
6
Specific inhibition studies relating to the Lewis blood-group system.与刘易斯血型系统相关的特异性抑制研究。
Nature. 1957 Nov 16;180(4594):1038-40. doi: 10.1038/1801038a0.
7
Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid galactosyltransferase.糖蛋白生物合成：甲状腺球蛋白的研究。甲状腺半乳糖基转移酶。
J Biol Chem. 1968 Dec 25;243(24):6529-37.
8
An a-N-acetyl-D-galactosaminyltransferase associated with the human blood-group A character.一种与人血型A特征相关的α-N-乙酰-D-半乳糖胺基转移酶。
Biochem J. 1968 Sep;109(2):315-7. doi: 10.1042/bj1090315.
9
An enzymic basis for blood type A in humans.人类A型血的酶学基础。
Arch Biochem Biophys. 1968 Mar 20;124(1):609-12. doi: 10.1016/0003-9861(68)90373-1.
10
Properties of some glycosyltransferases in embryonic chicken brain.胚胎鸡脑中某些糖基转移酶的特性
J Biol Chem. 1970 Dec 25;245(24):6607-15.

人血清和红细胞膜中的N-乙酰-D-半乳糖胺基转移酶

N-acetyl-D-galactosaminyltransferase in human serum and erythrocyte membranes.

作者信息

Kim Y S, Perdomo J, Bella A, Nordberg J

出版信息

Proc Natl Acad Sci U S A. 1971 Aug;68(8):1753-6. doi: 10.1073/pnas.68.8.1753.

DOI:10.1073/pnas.68.8.1753
PMID:5288760
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC389286/
Abstract

This study demonstrates the presence of an N-acetyl-D-galactosaminyltransferase in human serum and in erythrocyte membranes. This enzyme catalyzes the transfer of N-acetyl-D-galactosamine from UDP-N-acetyl-D-galactosamine to a mucin receptor and 2'-fucosyllactose that have blood group H activity and may be responsible, therefore, for blood group A antigenicity. It was present in the serum of individuals with blood group A or AB but was absent from those with blood group B or O. The activity measured in the erythrocyte membrane was low and did not show clear-cut separation among donors of different blood groups. The specificity of this enzyme in serum was suggested by the ability of 2'-fucosyllactose to act as an acceptor, as well as desialyzed porcine submaxillary mucin, while lactose and desialized fetuin failed to accept N-acetyl-D-galactosamine. The catalytic properties of the N-acetyl-D-galactosaminyltransferase from serum and from erythrocyte membranes were similar.

摘要

本研究证明人血清和红细胞膜中存在N - 乙酰 - D - 半乳糖胺基转移酶。该酶催化N - 乙酰 - D - 半乳糖胺从UDP - N - 乙酰 - D - 半乳糖胺转移至具有血型H活性的黏蛋白受体和2'-岩藻糖基乳糖，因此可能与血型A抗原性有关。它存在于A型或AB型血个体的血清中，而B型或O型血个体的血清中则不存在。在红细胞膜中测得的活性较低，且在不同血型供体之间未表现出明显差异。2'-岩藻糖基乳糖以及去唾液酸猪下颌黏蛋白作为受体的能力表明了该酶在血清中的特异性，而乳糖和去唾液酸胎球蛋白则不能接受N - 乙酰 - D - 半乳糖胺。血清和红细胞膜中的N - 乙酰 - D - 半乳糖胺基转移酶的催化特性相似。