Badet J, Ropars C, Salmon C
J Immunogenet. 1978 Aug;5(4):221-31. doi: 10.1111/j.1744-313x.1978.tb00650.x.
Thirteen cis AB persons from five families were examined for serum glycosyltransferase activities associated with the biosynthesis of A and B blood group characters. Their transferases were generally homogeneous within one family, except for A2/cis AB genotypes, whose A enzyme level was similar to the A2 normal sera, but they varied from one family to another. These activities differed quantitatively and qualitatively from A, B and AB normal sera. Studies of A transferase showed variations in the pH-dependent curve, the effect of cofactors and the capacity of conversion of O red cells into A-active cells. Moreover, A and B transferases behaved differently with respect to their relative levels than did AB heterozygous normal sera. The results were discussed and it was suggested that a mutation of a single enzyme transferring both galactose and N-acetyl-galactosamine could explain these properties.
对来自五个家族的13名顺式AB型个体进行了检测，以研究与A和B血型特征生物合成相关的血清糖基转移酶活性。除了A2/顺式AB基因型外，其家族内的转移酶通常是同质的，A2/顺式AB基因型的A酶水平与A2正常血清相似，但不同家族之间存在差异。这些活性在数量和质量上与A、B和AB正常血清不同。对A转移酶的研究表明，其pH依赖性曲线、辅因子的作用以及O型红细胞转化为A活性细胞的能力存在差异。此外，A和B转移酶的相对水平表现与AB杂合正常血清不同。对结果进行了讨论，并提出一种同时转移半乳糖和N-乙酰半乳糖胺的单一酶的突变可以解释这些特性。
