经鼻接种风疹疫苗的试验。
Trials of intranasally administered rubella vaccine.
作者信息
Hillary I B
出版信息
J Hyg (Lond). 1971 Dec;69(4):547-52. doi: 10.1017/s0022172400021811.
Abstract
No evidence of vaccine virus transmission was found in two studies where Wistar RA 27/3 rubella vaccine was administered intranasally. Vaccine was immunogenic in all of 23 vaccinated children in one study, while in the other only 5 of the 11 vaccinees developed antibody. The reduced seroconversion rate in the latter study appears to have been caused by one or a combination of factors, including the vaccination technique, the presence of infective nasal conditions in vaccinees and the titre of vaccine used.
摘要
在两项鼻内接种Wistar RA 27/3风疹疫苗的研究中，未发现疫苗病毒传播的证据。在一项研究中，23名接种疫苗的儿童均产生了免疫反应，而在另一项研究中，11名接种者中只有5人产生了抗体。后一项研究中血清转化率降低似乎是由一个或多个因素共同作用导致的，这些因素包括接种技术、接种者存在感染性鼻腔疾病以及所用疫苗的效价。
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本文引用的文献
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Presse Med (1893). 1967 Oct 21;75(43):2177-8.
2
Rubella-virus hemagglutination-inhibition test.风疹病毒血凝抑制试验
N Engl J Med. 1967 Mar 9;276(10):554-7. doi: 10.1056/NEJM196703092761006.
3
Attenuation of RA 27-3 rubella virus in WI-38 human diploid cells.RA 27-3风疹病毒在WI-38人二倍体细胞中的减毒
Am J Dis Child. 1969 Aug;118(2):178-85. doi: 10.1001/archpedi.1969.02100040180004.
4
Rubella vaccine trial in children.儿童风疹疫苗试验。
Br Med J. 1969 May 31;2(5656):531-2. doi: 10.1136/bmj.2.5656.531.
5
Rubella: reinfection of vaccinated and naturally immune persons exposed in an epidemic.风疹：在风疹流行期间，已接种疫苗者和自然免疫者再次感染。
N Engl J Med. 1970 Oct 8;283(15):771-8. doi: 10.1056/NEJM197010082831501.
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Clinical and serologic studies of an outbreak of rubella in a vaccinated population.在接种过疫苗人群中爆发风疹的临床及血清学研究
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