抗肿瘤药物在聚氰基丙烯酸烷基酯纳米颗粒上的吸附及其在小牛血清中的释放。
Adsorption of antineoplastic drugs to polyalkylcyanoacrylate nanoparticles and their release in calf serum.
作者信息
Couvreur P, Kante B, Roland M, Speiser P
出版信息
J Pharm Sci. 1979 Dec;68(12):1521-4. doi: 10.1002/jps.2600681215.
PMID:529043
Abstract
Conditions are described for attaching anticancer drugs to polyalkylcyanoacrylate nanoparticles, a new drug delivery system for cells that exhibit endocytic uptake. They are ultrafine, metabolizable, and able to associate with various drugs in a nonspecific manner. Data are given for the in vitro degradation and for drug release from this new drug carrier system.
摘要
文中描述了将抗癌药物附着于聚烷基氰基丙烯酸酯纳米颗粒的条件，聚烷基氰基丙烯酸酯纳米颗粒是一种用于表现出内吞摄取作用的细胞的新型药物递送系统。它们超细微、可代谢，并且能够以非特异性方式与各种药物结合。文中给出了关于这种新型药物载体系统的体外降解和药物释放的数据。
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