Tissue distribution of antitumor drugs associated with polyalkylcyanoacrylate nanoparticles.

Polymethylcyanoacrylate nanoparticles, polyethylcyanoacrylate nanoparticles, and free 3H-dactinomycin and 3H-vinblastine were studied with emphasis on their distribution pattern in rat tissues after intravenous administration. The adsorption of cytostatic drugs to polyalkylcyanoacrylate nanoparticles can modify drug distribution in tissues. Particularly with vinblastine, modification of drug disposition is important. Data are given concerning the formation and stability of nanoparticle--drug complexes. Polyalkylcyanoacrylate nanoparticles seem to be an interesting drug carrier owing to their size, structure, degradability, and drug sorptive properties.