[Studies on combined lesions. 22. Studies on serum proteins by means of CAF-electrophoresis in mice, treated with whole body radiation and with open skin wounds].

After combined injuries, much more pronounced changes in the protein composition of serum develop than simply after skin wounding or irradiation. A decrease was found in the prealbumin, albumin, alpha1-globulin and gamma-globulin fractions while the alpha2-globulin and beta-globulin fractions increased. If skin wounds were inflicted prior or almost simultaneously to irradiation, the serum protein changes as induced by irradiation become normalized earlier. I1 skin wounds were inflicted after irradiation they caused very pronounced alteration in the protein picture which develops in a course parallel to the increasing lethality. Only if the skin wounds were inflicted 21 days after irradiation, that they appeared to have nearly no influence in the form of augmenting protein changes. The gamma-globulin content increased considerably after the 14th day after irradiation. An additional skin wound, however, caused a depression of the gamma-globulins; but the values were still significantly higher than normal.