Merritt J C
J Natl Med Assoc. 1979 Jul;71(7):645-9.
Endogenous uveitis, with its ocular sequalae, accounts for a significant number of blind children in the world today. Even though these children are asymptomatic by ophthalmic history, they usually present with ocular pathology compatible with chronic intraocular inflammation. Although loss of vision is invariably due to cataract formation, fluorescein angiogram, binocular indirect ophthalmoloscopy, and fundus contact lens examination often reveal pathology of the optic nerve and retina, accounting for a significant degree of visual loss. While actual etiologic agents are usually not identified in the majority of children, toxoplasmosis, sarcoidosis, and childhood arthropathies occur with such high frequency that mention is made of these diseases. Conventional surgical procedures for ocular sequalae such as cataract and glaucoma, are known to yield poor results. Corticosteroids administered either topically, periocularly, or systemically appear to be of value in the treatment of these diseases, although control studies have not been done. Efforts to lessen the visual morbidity in these children should begin by a cross-fertilization of information between primary care physicians, pediatricians, and ophthalmologists.
内源性葡萄膜炎及其眼部后遗症，在当今世界导致大量儿童失明。尽管这些儿童根据眼科病史无症状，但他们通常表现出与慢性眼内炎症相符的眼部病变。虽然视力丧失总是由于白内障形成，但荧光素血管造影、双目间接检眼镜检查和眼底接触镜检查常常揭示视神经和视网膜的病变，这是导致相当程度视力丧失的原因。虽然大多数儿童通常无法确定实际病因，但弓形虫病、结节病和儿童关节炎的发生率很高，因此会提及这些疾病。已知针对白内障和青光眼等眼部后遗症的传统外科手术效果不佳。局部、眼周或全身使用皮质类固醇在治疗这些疾病中似乎有价值，尽管尚未进行对照研究。减轻这些儿童视觉发病率的努力应从初级保健医生、儿科医生和眼科医生之间的信息交叉融合开始。
