洋地黄在肺切除术中的应用及其意义。
Digitalis in pneumonectomy and its implication.
作者信息
Adebo O A, Singh A K
出版信息
J Natl Med Assoc. 1979 Jul;71(7):669-70.
Between 1968 and 1977, 87 patients underwent pneumonectomy at Rhode Island Hospital. Postoperatively, 25 patients developed arrhythmia (29 percent), giving rise to hemodynamic deterioration necessitating aggressive treatment. There were nine hospital deaths (10 percent). The effect of preoperative digitalis was analyzed in 68 patients over age 50 years.In Group 1, digoxin was not used until the onset of arrhythmia. There were 40 patients in this group; 18 developed arrhythmia (45 percent) with four deaths (22 percent).In Group 2, patients were given digitalis preoperatively. There were 28 patients; six developed arrhythmia (21 percent) with no deaths.Thus, the high incidence (45 percent in Group 1 and 21 percent in Group 2), as well as risk of mortality (4/18 patients) from arrhythmia following pneumonectomy, in patients over 50 years of age without digitalization, is a strong indication for preoperative digitalis.
1968年至1977年间，87例患者在罗德岛医院接受了肺切除术。术后，25例患者出现心律失常（29%），导致血流动力学恶化，需要积极治疗。有9例患者在医院死亡（10%）。对68例50岁以上患者术前使用洋地黄的效果进行了分析。在第1组中，直到心律失常发作才使用地高辛。该组有40例患者；18例出现心律失常（45%），4例死亡（22%）。在第2组中，患者术前给予洋地黄。该组有28例患者；6例出现心律失常（21%），无死亡病例。因此，50岁以上未进行洋地黄化的患者肺切除术后心律失常的高发生率（第1组为45%，第2组为21%）以及死亡风险（18例患者中有4例），有力地表明了术前使用洋地黄的必要性。
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