Nordeck E, Avenhaus H
Z Kardiol. 1975 May;64(5):411-8.
Antiarrhythmic drugs are known to cause AV-blockade. In animals and healthy humans the alcaloid of the gorse sparteine sulphate has been reported not to cause those side effects. We have studied in 10 patients with predamaged conduction system the grade of AV-blockade, the AV-interval and the intraventricular excitation spread by e.c.g. after i.v. injection of 200 mg sparteine sulphate (ajmalin, 50 mg i.v. as control). In 6 out of 10 patients no side effects have been observed. In 4 patients both sparteine and ajmalin injection caused higher graded AV-blockade. Our results suggest that sparteine sulphate like other antiarrhythmic drugs should not be administered to patients with a predamaged conduction system.
已知抗心律失常药物会引起房室传导阻滞。在动物和健康人体中，已报道金雀花碱硫酸司巴丁不会引起这些副作用。我们对10例传导系统预先受损的患者进行了研究，通过静脉注射200mg硫酸司巴丁（阿义马林，静脉注射50mg作为对照）后，利用心电图研究房室传导阻滞的程度、房室间期和心室内兴奋传导。10例患者中有6例未观察到副作用。4例患者注射司巴丁和阿义马林均导致更高程度的房室传导阻滞。我们的结果表明，硫酸司巴丁与其他抗心律失常药物一样，不应给予传导系统预先受损的患者。
