Satoh H, Suzuki T
Sangyo Igaku. 1979 May;21(3):246-9. doi: 10.1539/joh1959.21.246.
Mercury concentrations in the brain of man exposed to mercury vapor at or around the maximum permissible concentration were estimated by two mathematical models using informatins obtained from human and animal experiments. (formula: see text) Ac=concentration in the brain, C=concentration in air, V=ventilation volume, T=daily exposure time, R=proportion of mercury vapor retained after a single inhalation, D=proportion distributed to the brain, W=weight of the brain, b=elimination constant of mercury vapor in the brain, d=elimination constant of mercuric mercury in the brain, c=proportion of oxidization of elemental mercury in the brain. Model 1 is composed from a simple hypothesis that mercury vapor retained in the brain takes a single elimination coefficient, and in Model 2, a modification of Model 1, the part of elemental mercury retained in the brain is oxidized and thus has a different biological half-time from elemental mercury. During exposure to mercury vapor at the concentration of 0.05 mgHg/m3, estimated concentrations in the brain by Model 1 do not exceed a hypothetical critical concentration in the brain of 1.0 micrometerHg/g tissue but the estimated concentration by Model 2 exceeds this level.
使用从人体和动物实验获得的信息，通过两个数学模型估算了暴露于最大允许浓度或其附近汞蒸气的人的大脑中的汞浓度。（公式：见正文）Ac = 大脑中的浓度，C = 空气中的浓度，V = 通风量，T = 每日暴露时间，R = 单次吸入后保留的汞蒸气比例，D = 分布到大脑的比例，W = 大脑重量，b = 大脑中汞蒸气的消除常数，d = 大脑中汞汞的消除常数，c = 大脑中元素汞的氧化比例。模型1基于一个简单假设构建，即大脑中保留的汞蒸气具有单一消除系数，而在模型2中，对模型1进行了修正，大脑中保留的元素汞部分被氧化，因此其生物半衰期与元素汞不同。在暴露于浓度为0.05 mgHg/m³的汞蒸气期间，模型1估算的大脑浓度未超过大脑中假设的临界浓度1.0微克汞/克组织，但模型2估算的浓度超过了该水平。
