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良性颅内高压,尤其论及其在肥胖年轻女性中的发生情况。

Benign intracranial hypertension with particular reference to its occurrence in fat young women.

作者信息

Wilson D H, Gardner W J

出版信息

Can Med Assoc J. 1966 Jul 16;95(3):102-5.

Abstract

Benign intracranial hypertension (pseudotumor cerebri), a syndrome common to a number of disorders, is characterized by headaches and blurred vision. The patient is alert and has papilledema without localizing signs. Air studies show normal ventricles under increased pressure. The authors describe 61 consecutive cases of this pseudotumour, 48 of which were in fat young women, and propose that this group represents a clinical entity that has hitherto received little attention.In these 61 patients, 40 complete-exchange pneumoencephalograms showed normal ventricles, normal fluid volume and prominent cortical sulci. In 32, subtemporal decompression resulted in prompt and lasting relief. Three patients had late convulsive seizures after surgery. Seven patients had nasal quadrantanopsias, the implications of which are discussed. The authors believe that the high intracranial pressure in this condition is due to cerebral hyperemia, not brain edema. Further investigation will perhaps demonstrate a relationship between obesity, vascular dilatation and increased intracranial pressure.

摘要

良性颅内高压(假性脑瘤)是多种疾病共有的一种综合征,其特征为头痛和视力模糊。患者意识清醒,有视乳头水肿但无定位体征。气脑造影显示在压力升高情况下脑室正常。作者描述了连续61例这种假性肿瘤病例,其中48例为肥胖年轻女性,并提出这一组病例代表了一个迄今为止很少受到关注的临床实体。在这61例患者中,40次全交换气脑造影显示脑室正常、液体量正常且脑沟明显。32例患者经颞下减压后迅速且持久地缓解。3例患者术后出现迟发性惊厥发作。7例患者有鼻侧象限盲,文中对其影响进行了讨论。作者认为这种情况下的高颅内压是由于脑充血,而非脑水肿。进一步研究可能会揭示肥胖、血管扩张与颅内压升高之间的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2490/1936730/24c008bf36a4/canmedaj01173-0016-a.jpg

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