Bull World Health Organ. 1966;34(6):865-76.
A mass vaccination campaign of children under 3 years old was carried out in Ibadan in late 1964, following a marked increase in the incidence of paralytic poliomyelitis the previous year. Two doses of Sabin-strain attenuated poliomyelitis vaccine were given-the first of type 2 virus and the second of bivalent vaccine containing type 1 and type 3 viruses-with an interval of four weeks between doses. Although serological tests indicated a low antibody response, there was a pronounced and sustained fall in the incidence of the disease.It is concluded that the immunization schedules currently recommended in North America and Europe (namely, three doses at intervals of 4-8 weeks) are not suitable in Ibadan and similar cities in other parts of Africa, where the type of schedule used in this study is preferable. The virtual elimination of the disease from such regions is not at present a practical proposition, but the annual repetition of mass vaccination campaigns should prevent any increases in its incidence.
1964年末，在伊巴丹开展了针对3岁以下儿童的大规模疫苗接种活动，此前一年麻痹性脊髓灰质炎发病率显著上升。接种了两剂萨宾株减毒脊髓灰质炎疫苗，第一剂为2型病毒疫苗，第二剂为含1型和3型病毒的二价疫苗，两剂之间间隔四周。尽管血清学检测显示抗体反应较低，但该病的发病率出现了明显且持续的下降。得出的结论是，北美和欧洲目前推荐的免疫接种方案（即每隔4 - 8周接种三剂）在伊巴丹及非洲其他地区的类似城市并不适用，在这些地区本研究中使用的接种方案更为可取。目前在这些地区实际上无法消除该疾病，但每年重复开展大规模疫苗接种活动应能防止其发病率上升。
