Deen W M, Bohrer M P, Brenner B M
Kidney Int. 1979 Sep;16(3):353-65. doi: 10.1038/ki.1979.138.
Developments in the hydrodynamic theory of solute transport through porous membranes are reviewed, with emphasis on their application to macromolecule movement across capillary walls. A model that treats the capillary wall as a barrier containing uniform cylindrical pores, and permeating solutes as hard spheres, is shown to be successful in describing the size-selectivity of the glomerulus. Influences of various hemodynamic perturbations on solute transport are also accounted for by this approach. Possible extensions and modification of the theory, to account for the influence of molecular charge and other factors on glomerular permeability properties, are discussed.
本文综述了溶质通过多孔膜的流体动力学理论的发展，重点介绍了其在大分子跨毛细血管壁运动中的应用。一个将毛细血管壁视为包含均匀圆柱形孔的屏障，将渗透溶质视为硬球的模型，已被证明能成功描述肾小球的大小选择性。该方法还考虑了各种血液动力学扰动对溶质运输的影响。讨论了该理论可能的扩展和修正，以解释分子电荷和其他因素对肾小球通透性的影响。
