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无毛大鼠紫外线诱导皮肤红斑的产生:与有毛大鼠在抗炎药物筛选中的比较。

Production of ultraviolet-light-induced skin erythema in the hairless rat: a comparison with the haired rat in screening for anti-inflammatory drugs.

作者信息

Fox P K, Lewis A J

出版信息

Lab Anim. 1979 Oct;13(4):321-3. doi: 10.1258/002367779780943198.

DOI:10.1258/002367779780943198
PMID:529769
Abstract

The onset of this erythema in response to different times of exposure corresponds closely to that in the haired animal. Orally administered phenylbutazone (30 mg/kg) or subcutaneously administered fluocinolone acetonide (10 mg/kg) have an equivalent antierythemic effect on haired and hairless animals. The hairless rat may therefore be an attractive alternative to its haired counterpart in this model since, prior to irradiation, it requires no depilation--which itself may affect subsequent erythema production.

摘要

这种红斑对不同暴露时间的反应开始情况与有毛动物的情况密切对应。口服苯基丁氮酮(30毫克/千克)或皮下注射丙酮缩氟氢羟龙(10毫克/千克)对有毛和无毛动物具有同等的抗红斑作用。因此,在该模型中,无毛大鼠可能是有毛大鼠颇具吸引力的替代物,因为在辐照前,它无需脱毛,而脱毛本身可能会影响后续红斑的产生。

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Production of ultraviolet-light-induced skin erythema in the hairless rat: a comparison with the haired rat in screening for anti-inflammatory drugs.无毛大鼠紫外线诱导皮肤红斑的产生:与有毛大鼠在抗炎药物筛选中的比较。
Lab Anim. 1979 Oct;13(4):321-3. doi: 10.1258/002367779780943198.
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