Tani S, Noguchi M, Hosoda Y, Sugibayasi K, Morimoto Y
Life Sciences Research Center, Josai University, Saitama, Japan.
Exp Anim. 1998 Oct;47(4):253-6. doi: 10.1538/expanim.47.253.
The hairless rat (WBN/Kob-Ht), a dominant mutant rat derived from the Wistar strain, rarely develops spontaneous erythema of a progressive nature on its skin. Erythema was first observed at 8 weeks of age and the incidence at 20 weeks of age was about 4% in both males and females. Histopathologically, erythema was characterised by dermatitis induced by an immunological reaction. Areas of erythema in the skin were decreased by treatment with dexamethasone (1 mg/kg) or ciclosporin (25 or 50 mg/kg). These results suggested that erythema on the hairless rat could be used as an animal model of spontaneous dermatitis.
无毛大鼠（WBN/Kob-Ht）是源自Wistar品系的显性突变大鼠，其皮肤很少出现进行性自发性红斑。红斑最早在8周龄时被观察到，20周龄时雄性和雌性的发病率均约为4%。组织病理学上，红斑的特征是由免疫反应诱导的皮炎。用地塞米松（1mg/kg）或环孢素（25或50mg/kg）治疗可减少皮肤红斑区域。这些结果表明，无毛大鼠的红斑可作为自发性皮炎的动物模型。
