Inwang E E, Khan M A, Brown A W
Bull World Health Organ. 1967;36(3):409-21.
The yellow fever mosquito Aedes aegypti has developed resistance to DDT in the Caribbean region and in South-East Asia, but not in West Africa. Therefore West African strains were compared with South-East Asian strains for their response to laboratory selection with DDT. It was found that West African strains were much slower to respond initially, but eventually could build up a high degree of DDT-resistance. By crossing and backcrossing with a susceptible marker-gene strain, it was found that this resistance was due to a single gene linked with the gene y (yellow) on chromosome 2 at a cross-over distance of approximately 35 units in an Upper Volta strain as in a Bangkok strain; interstrain crosses indicated that the gene was the same as that in a Trinidad strain and in one from Penang. Dieldrin-resistance could be readily induced in the Upper Volta strain and proved to be due to a gene also linked with y but at a crossover distance of approximately 25 units, comparable to that in Caribbean strains previously studied. Material from Karachi, West Pakistan, developed a dieldrin-resistance also showing 25% crossing over with y, and a DDT-resistance also linked with this chromosome-2 marker gene.
黄热病蚊子埃及伊蚊在加勒比地区和东南亚已对滴滴涕产生抗性，但在西非尚未出现这种情况。因此，对西非品系和东南亚品系进行了比较，观察它们对滴滴涕实验室选育的反应。结果发现，西非品系最初的反应要慢得多，但最终能够产生高度的滴滴涕抗性。通过与一个带有敏感标记基因的品系进行杂交和回交，发现这种抗性是由一个与位于2号染色体上的y（黄色）基因相连的单一基因引起的，在上沃尔特品系中，其交换距离约为35个单位，与曼谷品系相同；品系间杂交表明，该基因与特立尼达品系和槟城一个品系中的基因相同。在上沃尔特品系中很容易诱导出对狄氏剂的抗性，事实证明这是由一个也与y相连的基因引起的，但交换距离约为25个单位，与先前研究的加勒比品系相当。来自西巴基斯坦卡拉奇的材料也产生了对狄氏剂的抗性，与y的交换率也为25%，并且对滴滴涕的抗性也与这个2号染色体标记基因有关。
