FOX I
Bull World Health Organ. 1961;24(4-5):489-94.
Failure to control Aëdes aegypti in Puerto Rico has suggested resistance to the insecticides, particularly DDT. A laboratory colony (named Isla Verde strain) was established from material obtained near the International Airport. This strain proved highly resistant to DDT and dieldrin as well as various other insecticides. The scientific and practical significance of this is far-reaching. Heretofore, it was thought that populations of Aëdes aegypti could be resistant to the DDT group of insecticides or to the dieldrin group but not to both, and that one type of resistance involved biochemical, toxicological and genetic characteristics different from the other. This theory must now be modified or even abandoned. From the practical point of view, it is clear that the continued use of DDT or dieldrin for Aëdes aegypti control in Puerto Rico is questionable, for it is not wise to attempt to overcome high resistance by increasing the concentration or rate of application. Further, the situation demonstrated for Puerto Rico may also obtain in other islands of the Caribbean where Aëdes aegypti is known to be DDT-resistant.
在波多黎各未能控制埃及伊蚊，这表明其对杀虫剂产生了抗性，尤其是对滴滴涕。从国际机场附近获取的材料建立了一个实验室种群（名为伊斯拉贝尔德品系）。该品系被证明对滴滴涕、狄氏剂以及其他多种杀虫剂具有高度抗性。这一情况的科学和实际意义影响深远。在此之前，人们认为埃及伊蚊种群可能对滴滴涕类杀虫剂或狄氏剂类杀虫剂产生抗性，但不会对两者都产生抗性，并且一种抗性类型所涉及的生化、毒理学和遗传特性与另一种不同。现在必须对这一理论进行修正甚至摒弃。从实际角度来看，很明显在波多黎各继续使用滴滴涕或狄氏剂来控制埃及伊蚊是有问题的，因为试图通过提高浓度或施用量来克服高抗性是不明智的。此外，在已知埃及伊蚊对滴滴涕有抗性的加勒比其他岛屿，可能也存在与波多黎各类似的情况。
