Tolderlund K, Bunch-Christensen K, Guld J
Bull World Health Organ. 1967;36(5):759-69.
A five-year study has shown that the tuberculin sensitivity of guinea-pigs seemingly wanes completely after BCG-vaccination over the course of years, but it can be restored by a single injection of tuberculin to the same level as that found in newly vaccinated animals of the same age. In contrast the acquired resistance to tuberculosis in guinea-pigs vaccinated several years previously is of intermediate strength, inferior to that of the newly vaccinated, and is not restored (apparently not influenced at all) by the injection of tuberculin. It is thus not possible to follow the course and eventual waning of resistance by means of repeated tuberculin testing, and the very common practice of timing revaccination of the individual according to the outcome of such testing must therefore be considered to be without scientific basis.
一项为期五年的研究表明，卡介苗接种多年后，豚鼠的结核菌素敏感性似乎会完全消退，但单次注射结核菌素可将其恢复到与同龄新接种动物相同的水平。相比之下，几年前接种过疫苗的豚鼠对结核病的获得性抵抗力处于中等强度，低于新接种的豚鼠，并且注射结核菌素不会使其恢复（显然完全不受影响）。因此，不可能通过反复进行结核菌素检测来追踪抵抗力的变化过程及最终消退情况，所以根据此类检测结果来确定个体再次接种疫苗的时机这种非常普遍的做法必须被认为是没有科学依据的。
