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结核感染与重复检测。对卡介苗接种豚鼠的影响。

Tuberculosis infection and the repeat test. Effect in BCG-vaccinated guinea pigs.

作者信息

Lehmann E H

出版信息

Scand J Respir Dis. 1978 Aug;59(4):194-8.

PMID:99809
Abstract

Groups of BCG-vaccinated guinea pigs were infected with Mycobacterium tuberculosis and the course of tuberculin reactions before and after was studied. The infection led to reactions that were accelerated as if repeated tests had been given, but were larger than in such cases. Acceleration of reactions due to previous testing was present 1 week, but not 4 weeks after the start of the infection. Possibly, in cellular immunity in general, absence of the repeat test effect may be interpreted as a sign that specific antigen stimulation is taking place, and diagnostic tests could be constructed on this basis.

摘要

给接种卡介苗的豚鼠群体感染结核分枝杆菌,并研究感染前后结核菌素反应的过程。感染导致反应加速,就好像进行了重复测试一样,但反应比这种情况下更大。由于先前测试导致的反应加速在感染开始后1周出现,但在4周后未出现。一般来说,在细胞免疫中,重复测试效应的缺失可能被解释为正在发生特异性抗原刺激的迹象,并且可以在此基础上构建诊断测试。

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