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1
The use of penicillamine as an adjuvant to tartar emetic in the treatment of experimental schistosomiasis.青霉胺作为吐酒石辅助剂用于治疗实验性血吸虫病。
Bull World Health Organ. 1967;37(3):387-92.
2
Penicillamine as an adjuvant to antimonial therapy of schistosomiasis: effect on liver function tests in rabbits and on antischistosomal activity.青霉胺作为锑剂治疗血吸虫病的辅助药物：对兔肝功能试验及抗血吸虫活性的影响。
Bull World Health Organ. 1973;48(4):415-20.
3
Schistosoma mansoni: early antimonial treatment of infected mice.
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4
Experimental chemotherapy of schistosomiasis. VII. Laboratory and clinical trials with sodium antimony dimethylcysteine tartrate (NaP).
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5
Comparative antimony disposition following administration of tartar emetic and sodium antimony dimercaptosuccinate (Astiban) to hamsters infected with Schistosoma mansoni.对感染曼氏血吸虫的仓鼠给予吐酒石和二巯基丁二酸锑钠（锑波芬）后锑的处置情况比较。
East Afr Med J. 1967 Jan;44(1):1-8.
6
The value of glucosamine in increasing the efficacy of tartar emetic in experimental schistosomiasis.
J Egypt Public Health Assoc. 1972;47(2):81-7.
7
The effect of penicillamine in the treatment of experimental schistosomiasis with tartar emetic.青霉胺在吐酒石治疗实验性血吸虫病中的作用。
Ann Trop Med Parasitol. 1971 Jun;65(2):233-44. doi: 10.1080/00034983.1971.11720831.
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A comparative study of dipterex and tartar emetic in the treatment of urinary schistosomiasis.敌百虫与吐酒石治疗尿路血吸虫病的对比研究。
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The effect of the antibilharzial compound (Bilharcid) on Schistosoma mansoni in vitro and in vivo.抗血吸虫化合物（Bilharcid）对曼氏血吸虫的体外和体内作用。
Egypt J Bilharz. 1976;3(2):239-45.

引用本文的文献

1
Significance of the chemotherapeutic index in the treatment of schistosomiasis with antimony compounds.化疗指数在锑化合物治疗血吸虫病中的意义
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2
Penicillamine as an adjuvant to antimonial therapy of schistosomiasis: effect on liver function tests in rabbits and on antischistosomal activity.青霉胺作为锑剂治疗血吸虫病的辅助药物：对兔肝功能试验及抗血吸虫活性的影响。
Bull World Health Organ. 1973;48(4):415-20.
3
Effect of cysteine on the hepatic toxicity and antischistosomal activity of antimonyl potassium tartrate.半胱氨酸对酒石酸锑钾肝毒性及抗血吸虫活性的影响。
Bull World Health Organ. 1976;53(4):379-84.

本文引用的文献

1
Carbohydrate metabolism of schistosoma mansoni.曼氏血吸虫的碳水化合物代谢
J Gen Physiol. 1950 May 20;33(5):475-95. doi: 10.1085/jgp.33.5.475.
2
Effect of naphthoquinones on Schistosoma mansoni in vitro and in vivo.萘醌对曼氏血吸虫的体内外作用
J Pharmacol Exp Ther. 1951 Feb;101(2):210-29.
3
[EFFECT OF D-PENICILLAMINE ON THE EXCRETION OF MERCURY AND LEAD IN THE URINE].[D-青霉胺对尿汞和尿铅排泄的影响]
Prac Lek. 1964 Dec;16:433-5.
4
ENDOGENOUS COPPER CLEARANCE IN WILSON'S DISEASE: A STUDY OF THE MODE OF ACTION OF PENICILLAMINE.威尔逊病的内源性铜清除：青霉胺作用模式的研究
Clin Sci. 1964 Jun;26:461-9.
5
THE EFFECTS OF ANTIMONY UPTAKE ON THE LOCATION AND PAIRING OF SCHISTOSOMA MANSONI.锑摄取对曼氏血吸虫定位和配对的影响。
Br J Pharmacol Chemother. 1964 Apr;22(2):342-8. doi: 10.1111/j.1476-5381.1964.tb02038.x.
6
[NEPHROTIC SYNDROME AFTER PROLONGED USE OF A MERCURIAL OINTMENT. MERCURY EXCRETION DURING TREATMENT WITH BAL AND N-ACETYL-DL-PENICILLAMINE].[长期使用汞软膏后出现肾病综合征。用二巯丙醇和N-乙酰-DL-青霉胺治疗期间的汞排泄情况]
Ned Tijdschr Geneeskd. 1964 Feb 8;108:251-5.
7
STUDIES ON METAL COMPLEXES OF DRUGS; D-PENICILLAMINE AND N-ACETYL-D-PENICILLAMINE.药物金属配合物的研究；D-青霉胺和N-乙酰-D-青霉胺
Pharm Weekbl. 1964 Mar 20;99:289-309.
8
FILTERABLE AND NON-FILTERABLE SERUM COPPER. 1. THE ACTION OF PENICILLAMINE.
Clin Sci. 1963 Dec;25:405-11.
9
Albuminuria and the nephrotic syndrome following exposure to mercury and its compounds.接触汞及其化合物后出现的蛋白尿和肾病综合征。
Q J Med. 1962 Oct;31:403-18.
10
Rapid hepatic shift of worms in mice infected with Schistosoma mansoni after a single injection of tartar emetic.单次注射吐酒石后感染曼氏血吸虫的小鼠体内蠕虫的快速肝脏转移
Nature. 1962 May 26;194:780-1. doi: 10.1038/194780b0.

青霉胺作为吐酒石辅助剂用于治疗实验性血吸虫病。

The use of penicillamine as an adjuvant to tartar emetic in the treatment of experimental schistosomiasis.

作者信息

Khayyal M T, Girgis N I, McConnell E

出版信息

Bull World Health Organ. 1967;37(3):387-92.

PMID:5301382
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2554273/
Abstract

One of the principal drawbacks of antimonial therapy in schistosomiasis has been the prevalence of annoying, and sometimes dangerous, side-effects. The adjuvant administration of chelating agents offers a possible solution to this problem, providing this can be achieved without appreciably decreasing the therapeutic effect of the drug.The authors found that the chelating agent penicillamine lowered the toxicity of tartar emetic for mice and hamsters without affecting the tissue uptake of antimony. When administered in a similar manner to hamsters infected with Schistosoma mansoni there was no effect on the uptake of antimony by the parasites, or on the cure rate. This suggests a potential usefulness of penicillamine in antimony therapy.

摘要

锑剂治疗血吸虫病的一个主要缺点是常出现令人烦恼甚至有时危险的副作用。辅助使用螯合剂或许能解决这一问题，前提是这样做不会显著降低药物的治疗效果。作者发现螯合剂青霉胺可降低吐酒石对小鼠和仓鼠的毒性，且不影响锑在组织中的摄取。以类似方式给感染曼氏血吸虫的仓鼠用药时，对寄生虫摄取锑或治愈率均无影响。这表明青霉胺在锑剂治疗中可能具有潜在用途。