麻风病与遗传学。对过去研究的综述及对未来调查的评论
Leprosy and genetics. A review of past research with remarks concerning future investigations.
作者信息
Beiguelman B
出版信息
Bull World Health Organ. 1967;37(3):461-76.
Abstract
The few geneticists who are interested in leprosy have been working in this field only since 1962, and have made little progress in solving the problems presented by susceptibility to this disease.This paper reviews the research that has been conducted, with particular reference to the search for associations between leprosy and certain genetic markers. In each area, the advantages and limitations of different techniques are described, and attention is drawn to sources of bias that may invalidate many of the results that have been published. Of particular interest is the discussion of a new technique for evaluating resistance to-leprosy. The proposed technique is based upon the in vitro transformation of blood monocytes into macrophages, and the observation of their behaviour against Mycobacterium leprae.
摘要
少数对麻风病感兴趣的遗传学家自1962年起才开始涉足该领域，在解决麻风病易感性所带来的问题方面进展甚微。本文回顾了已开展的研究，特别提及了对麻风病与某些遗传标记之间关联的探索。在每个领域，都描述了不同技术的优缺点，并指出了可能使许多已发表结果无效的偏差来源。特别值得关注的是对一种评估麻风病抵抗力的新技术的讨论。所提出的技术基于体外将血液单核细胞转化为巨噬细胞，并观察它们对麻风分枝杆菌的反应。
相似文献
1
Leprosy and genetics. A review of past research with remarks concerning future investigations.麻风病与遗传学。对过去研究的综述及对未来调查的评论
Bull World Health Organ. 1967;37(3):461-76.
2
[Leprosy, a pillar of human genetics of infectious diseases].[麻风病，人类传染病遗传学的一个支柱]
Pathol Biol (Paris). 2013 Jun;61(3):120-8. doi: 10.1016/j.patbio.2013.03.003. Epub 2013 May 24.
3
[The genetic susceptibility to leprosy in humans].[人类对麻风病的遗传易感性]
Acta Leprol. 1996;10(1):11-27.
4
Genetic dissection of immunity in leprosy.麻风病免疫的遗传学剖析。
Curr Opin Immunol. 2005 Feb;17(1):44-8. doi: 10.1016/j.coi.2004.11.006.
5
Susceptibility to leprosy may be conditioned by an interaction between the NRAMP1 promoter polymorphisms and the lepromin response.麻风易感性可能由NRAMP1启动子多态性与麻风菌素反应之间的相互作用所决定。
Int J Lepr Other Mycobact Dis. 2004 Dec;72(4):457-67. doi: 10.1489/1544-581X(2004)72<457:STLMBC>2.0.CO;2.
6
Associations between HLA-DRB1 alleles and leprosy in an Indonesian population.印度尼西亚人群中HLA - DRB1等位基因与麻风病的关联。
Int J Lepr Other Mycobact Dis. 1997 Jun;65(2):190-6.
7
The immunobiology of leprosy.麻风病的免疫生物学
Int Rev Exp Pathol. 1986;28:45-78.
8
Genetic susceptibility to leprosy on a Caribbean Island: linkage analysis with five markers.加勒比海岛屿上麻风病的遗传易感性：与五个标记的连锁分析
Int J Lepr Other Mycobact Dis. 1989 Jun;57(2):465-71.
9
Linkage analysis of susceptibility to leprosy type using an IBD regression method.
Genes Immun. 2004 May;5(3):221-5. doi: 10.1038/sj.gene.6364062.
10
Ancient DNA analysis - An established technique in charting the evolution of tuberculosis and leprosy.古代DNA分析——绘制结核病和麻风病进化图谱的一项成熟技术。
Tuberculosis (Edinb). 2015 Jun;95 Suppl 1:S140-4. doi: 10.1016/j.tube.2015.02.020. Epub 2015 Feb 13.
引用本文的文献
1
Leukocyte antimicrobial function in patients with leprosy.麻风病患者的白细胞抗菌功能。
J Clin Invest. 1974 Feb;53(2):380-6. doi: 10.1172/JCI107570.
2
Failure to induce delayed-type hypersensitivity to Mycobacterium leprae in long-term treated lepromatous leprosy patients.长期治疗的瘤型麻风患者对麻风分枝杆菌诱导迟发型超敏反应失败。
Clin Exp Immunol. 1981 Jun;44(3):507-11.
3
Immunological problems in leprosy research. 1. Clinical and pathological spectrum of leprosy.麻风病研究中的免疫学问题。1. 麻风病的临床与病理谱
Bull World Health Organ. 1970;43(6):879-90.
4
5
Cell-mediated immunological processes in leprosy.麻风病中的细胞介导免疫过程。
Bull World Health Organ. 1969;41(6):779-92. doi: 10.5935/0305-7518.19700030.
6
A test for the determination of competency in clearing bacilli in leprosy patients.一项用于测定麻风病患者清除杆菌能力的测试。
Bull World Health Organ. 1972;46(6):821-6.
7
Leprosy.麻风病
Clin Microbiol Rev. 1988 Jul;1(3):330-48. doi: 10.1128/CMR.1.3.330.
8
Effects of activated macrophages on Mycobacterium leprae.活化巨噬细胞对麻风分枝杆菌的作用。
Infect Immun. 1991 Sep;59(9):2864-9. doi: 10.1128/iai.59.9.2864-2869.1991.
9
Multiple skin testing in leprosy.麻风病的多项皮肤试验
J Hyg (Lond). 1975 Aug;75(1):57-68. doi: 10.1017/s0022172400047069.
10
Impairment of cell-mediated immune responses by infection with Mycobacterium lepraemurium.感染鼠麻风杆菌导致细胞介导的免疫反应受损。
Infect Immun. 1977 Oct;18(1):157-64. doi: 10.1128/iai.18.1.157-164.1977.
本文引用的文献
1
The Relationship between Chemical Constitution and Taste.化学组成与味道之间的关系。
Proc Natl Acad Sci U S A. 1932 Jan;18(1):115-20. doi: 10.1073/pnas.18.1.115.
2
The measurement of taste sensitivity to phenylthiourea.对苯硫脲味觉敏感度的测量。
Ann Eugen. 1949 Oct;15(1):24-31. doi: 10.1111/j.1469-1809.1949.tb02419.x.
3
Taste sensitivity to phenylthiourea in goitre and diabetes.甲状腺肿和糖尿病患者对苯硫脲的味觉敏感性
Lancet. 1949 Dec 3;2(6588):1038. doi: 10.1016/s0140-6736(49)91605-0.
4
ABO blood-groups and gastric acidity.ABO血型与胃酸度
Lancet. 1955 Jul 9;269(6880):52-5. doi: 10.1016/s0140-6736(55)92159-0.
5
OBSERVATION ON THE FREQUENCY OF A.B.O. AND RH BLOOD GROUPS IN LEPROSY AND NON-LEPROSY PEOPLE IN GHANA.
Lepr Rev. 1965 Apr;36:73-4. doi: 10.5935/0305-7518.19650017.
6
A "NEW" ANTIGEN IN LEUKEMIA SERA.白血病血清中的一种“新”抗原。
JAMA. 1965 Feb 15;191:541-6. doi: 10.1001/jama.1965.03080070025007.
7
SULPHONE RESISTANCE IN LEPROSY. AN EXPERIMENTAL AND CLINICAL STUDY.麻风病中的砜类耐药性。一项实验与临床研究。
Lancet. 1964 Sep 26;2(7361):673-4. doi: 10.1016/s0140-6736(64)92482-1.
8
DOES GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY MODIFY THE COURSE OF LEPROSY OR ITS TREATMENT.
Lepr Rev. 1964 Jul;35:149-56. doi: 10.5935/0305-7518.19640032.
9
TASTE SENSITIVITY TO PHENYLTHIOUREA AND DRUGS WITH ANTI-LEPROTIC EFFECT.对苯硫脲及具有抗麻风作用药物的味觉敏感性。
Acta Genet Med Gemellol (Roma). 1964 Apr;13:200-2. doi: 10.1017/s1120962300015845.
10
TASTE SENSITIVITY TO PHENYLTHIOUREA AND MENSTRUATION.对苯硫脲的味觉敏感性与月经
Acta Genet Med Gemellol (Roma). 1964 Apr;13:197-9. doi: 10.1017/s1120962300015833.
Zotero 插件