Beiguelman B
Bull World Health Organ. 1967;37(3):461-76.
The few geneticists who are interested in leprosy have been working in this field only since 1962, and have made little progress in solving the problems presented by susceptibility to this disease.This paper reviews the research that has been conducted, with particular reference to the search for associations between leprosy and certain genetic markers. In each area, the advantages and limitations of different techniques are described, and attention is drawn to sources of bias that may invalidate many of the results that have been published. Of particular interest is the discussion of a new technique for evaluating resistance to-leprosy. The proposed technique is based upon the in vitro transformation of blood monocytes into macrophages, and the observation of their behaviour against Mycobacterium leprae.
少数对麻风病感兴趣的遗传学家自1962年起才开始涉足该领域，在解决麻风病易感性所带来的问题方面进展甚微。本文回顾了已开展的研究，特别提及了对麻风病与某些遗传标记之间关联的探索。在每个领域，都描述了不同技术的优缺点，并指出了可能使许多已发表结果无效的偏差来源。特别值得关注的是对一种评估麻风病抵抗力的新技术的讨论。所提出的技术基于体外将血液单核细胞转化为巨噬细胞，并观察它们对麻风分枝杆菌的反应。
