Bullock W E, Evans P E, Filomeno A R
Infect Immun. 1977 Oct;18(1):157-64. doi: 10.1128/iai.18.1.157-164.1977.
The effect of chronic infection with Mycobacterium lepraemurium upon cell-mediated immune responses was studied in Lewis rats. Rats infected for 40 to 175 days were completely protected from attempted induction of experimental adjuvant disease, and the severity of experimental allergic encephalomyelitis in leprous rats was markedly attenuated. Full manifestations of each autoimmune disease were expressed in littermate control groups. Skin homograft rejection by infected rats was significantly impaired (P less than 0.001) as was the delayed-type hypersensitivity response to sheep erythrocytes (P less than 0.02). It is suggested that chronic infection with M. lepraemurium exerts a nonspecific inhibitory effect on cell-mediated immunity by perturbation of normal lymphocyte recirculation and by induction of immuno-suppressor cell activity.
在Lewis大鼠中研究了感染鼠麻风杆菌慢性感染对细胞介导免疫反应的影响。感染40至175天的大鼠对诱导实验性佐剂病具有完全的抵抗力，并且麻风大鼠中实验性变应性脑脊髓炎的严重程度明显减轻。在同窝对照中每种自身免疫病都表现出完全的症状。感染大鼠对皮肤同种异体移植的排斥显著受损（P小于0.001），对绵羊红细胞的迟发型超敏反应也是如此（P小于0.02）。提示鼠麻风杆菌慢性感染通过干扰正常淋巴细胞再循环和诱导免疫抑制细胞活性，对细胞介导的免疫产生非特异性抑制作用。
