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感染鼠麻风杆菌导致细胞介导的免疫反应受损。

Impairment of cell-mediated immune responses by infection with Mycobacterium lepraemurium.

作者信息

Bullock W E, Evans P E, Filomeno A R

出版信息

Infect Immun. 1977 Oct;18(1):157-64. doi: 10.1128/iai.18.1.157-164.1977.

DOI:10.1128/iai.18.1.157-164.1977
PMID:409683
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC421208/
Abstract

The effect of chronic infection with Mycobacterium lepraemurium upon cell-mediated immune responses was studied in Lewis rats. Rats infected for 40 to 175 days were completely protected from attempted induction of experimental adjuvant disease, and the severity of experimental allergic encephalomyelitis in leprous rats was markedly attenuated. Full manifestations of each autoimmune disease were expressed in littermate control groups. Skin homograft rejection by infected rats was significantly impaired (P less than 0.001) as was the delayed-type hypersensitivity response to sheep erythrocytes (P less than 0.02). It is suggested that chronic infection with M. lepraemurium exerts a nonspecific inhibitory effect on cell-mediated immunity by perturbation of normal lymphocyte recirculation and by induction of immuno-suppressor cell activity.

摘要

在Lewis大鼠中研究了感染鼠麻风杆菌慢性感染对细胞介导免疫反应的影响。感染40至175天的大鼠对诱导实验性佐剂病具有完全的抵抗力，并且麻风大鼠中实验性变应性脑脊髓炎的严重程度明显减轻。在同窝对照中每种自身免疫病都表现出完全的症状。感染大鼠对皮肤同种异体移植的排斥显著受损（P小于0.001），对绵羊红细胞的迟发型超敏反应也是如此（P小于0.02）。提示鼠麻风杆菌慢性感染通过干扰正常淋巴细胞再循环和诱导免疫抑制细胞活性，对细胞介导的免疫产生非特异性抑制作用。

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本文引用的文献

1
Impairment of immunological reactivity in guinea pigs by prior injection of adjuvant.预先注射佐剂对豚鼠免疫反应性的损害。
Nature. 1962 Feb 24;193:789-90. doi: 10.1038/193789a0.
2
Transfer of allergic encephalomyelitis in rats by means of lymph node cells.通过淋巴结细胞在大鼠中传播过敏性脑脊髓炎。
J Exp Med. 1960 Jan 1;111(1):119-36. doi: 10.1084/jem.111.1.119.
3
EFFECT OF SENSITIZATION TO BSA ON ADJUVANT DISEASE IN NORMAL AND NEONATALLY THYMECTOMIZED RATS.牛血清白蛋白致敏对正常及新生期切除胸腺大鼠佐剂病的影响
Proc Soc Exp Biol Med. 1965 Jul;119:676-8. doi: 10.3181/00379727-119-30269.
4
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS: PROTECTION EXPERIMENTS WITH ENCEPHALITOGENIC FACTOR AND TUBERCLE FRACTIONS.实验性变应性脑脊髓炎：用致脑炎因子和结核菌素组分进行的保护实验。
Ann N Y Acad Sci. 1965 Mar 31;122:346-55. doi: 10.1111/j.1749-6632.1965.tb20219.x.
5
THE PROBLEM OF PREVENTION AND CONTROL OF AUTO-ALLERGIC INFLAMMATION IN THE NERVOUS SYSTEM.神经系统自身过敏性炎症的预防与控制问题
Z Immunitats Allergieforsch. 1964 Mar;126:209-16.
6
Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. II. Evidence that the disease is a disseminated immunologic response to exogenous antigen.关于注射分枝杆菌佐剂诱导大鼠产生关节炎及其他病变的研究。II. 该疾病是对外源抗原的一种播散性免疫反应的证据。
J Immunol. 1960 Oct;85:403-17.
7
The migration of cells through chronically inflamed tissues.细胞通过慢性炎症组织的迁移。
J Pathol. 1970 Jan;100(1):21-9. doi: 10.1002/path.1711000104.
8
Passive transfer of adjuvant-induced arthritis and allergic encephalomyelitis in rats using thoracic duct lymphocytes.使用胸导管淋巴细胞被动转移佐剂诱导的大鼠关节炎和过敏性脑脊髓炎
Nature. 1969 Dec 27;224(5226):1322. doi: 10.1038/2241322a0.
9
Suppression of delayed hypersensitivity by antigen and antibody. Is a common precursor cell responsible for both delayed hypersensitivity and antibody formation?抗原和抗体对迟发型超敏反应的抑制作用。是否存在一种共同的前体细胞，它同时负责迟发型超敏反应和抗体形成？
Immunology. 1968 Aug;15(2):159-71.
10
Leprosy and genetics. A review of past research with remarks concerning future investigations.麻风病与遗传学。对过去研究的综述及对未来调查的评论
Bull World Health Organ. 1967;37(3):461-76.

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